Molecular structure of MPEP hydrochloride, CAS Number: 96206-92-7
MPEP hydrochloride (CAS 96206-92-7)
Alternate Names:
6-Methyl-2-(phenylethynyl)-pyridine HCl; 2- methyl- 6- (2- phenylethynyl)- pyridine, monohydrochloride
Application:
MPEP hydrochloride is a selective antagonist of the mGluR5 receptor
CAS Number:
96206-92-7
Purity:
≥98%
Molecular Weight:
229.71
Molecular Formula:
C14H11N•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MPEP hydrochloride is a potent and selective antagonist of the mGluR5 receptor (metabotropic glutamate receptor subtype 5). MPEP hydrochloride positively modulates the hmGluR4 in a recombinant expression system, and the effect of MPEP hydrochloride is fully dependent on the activation of the orthosteric agonist L-AP4. MPEP hydrochloride reduces DHPG-induced excitations but not the excitations induced by AMPA. MPEP hydrochloride is an activator of mGluR-4.
MPEP hydrochloride (CAS 96206-92-7) References
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- Effect of metabotropic glutamate 5 receptor antagonists on morphine efficacy and tolerance in rats with neuropathic pain. | Zhou, Q., et al. 2013. Eur J Pharmacol. 718: 17-23. PMID: 24041921
- Neurotensin speeds inhibition of dopamine neurons through temporal modulation of GABAA and GABAB receptor-mediated synaptic input. | Tschumi, CW. and Beckstead, MJ. 2018. Neuropharmacology. 131: 414-423. PMID: 29307543
- Involvement of metabotropic glutamate receptor 5 in ethanol regulation of NMDA receptor activity in rat substantia gelatinosa neurons. | Lai, CC., et al. 2019. Life Sci. 233: 116729. PMID: 31386876
- Targeting the inhibition of fatty acid amide hydrolase ameliorate the endocannabinoid-mediated synaptic dysfunction in a valproic acid-induced rat model of Autism. | Wu, HF., et al. 2020. Neuropharmacology. 162: 107736. PMID: 31398381
- Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling. | Tschumi, CW., et al. 2022. J Neurosci. 42: 6186-6194. PMID: 35794014
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Inhibitor of:
Cerebellin 4, GABAC Rρ2, Homer-1, mGluR-1a, mGluR-2, mGluR-5, NGL-1, Olfr748, Olfr749, Olfr750, and TMEM132E.Activator of:
LRRTM2, and mGluR-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MPEP hydrochloride, 10 mg | sc-279454A | 10 mg | $133.00 | |||
MPEP hydrochloride, 50 mg | sc-279454 | 50 mg | $510.00 |