Molecular structure of LY 341495, CAS Number: 201943-63-7
LY 341495 (CAS 201943-63-7)
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Alternate Names:
(2S)-2-Amino-2-[(1S,2S)-2-carboxycy cloprop-1-yl]-3-(xanth-9-yl) propanoic acid
Application:
LY 341495 is a potent and selective group II metabotropic glutamate receptor antagonist
CAS Number:
201943-63-7
Molecular Weight:
353.37
Molecular Formula:
C20H19NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY 341495 may act to be a highly potent and selective group II metabotropic glutamate receptor (mGluR-2) antagonist with Ki / IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGluR-2, mGluR-3, mGluR-8, mGluR-7a, mGluR-1a, mGluR-5a and mGluR-4a.LY 341495 has garnered attention for its potential utility in drug synthesis and research endeavors. This compound, derived from D-alanine, an essential amino acid present in proteins and peptides.
LY 341495 (CAS 201943-63-7) References
- Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat. | Mills, CD., et al. 2001. J Neurochem. 79: 835-48. PMID: 11723176
- L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors. | Chiechio, S., et al. 2002. Mol Pharmacol. 61: 989-96. PMID: 11961116
- Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus. | Shen, KZ. and Johnson, SW. 2003. J Physiol. 553: 489-96. PMID: 14500768
- Distinct properties of carbachol- and DHPG-induced network oscillations in hippocampal slices. | Pálhalmi, J., et al. 2004. Neuropharmacology. 47: 381-9. PMID: 15275827
- NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons. | Bergeron, R., et al. 2005. Neuropsychopharmacology. 30: 7-16. PMID: 15354184
- The effects of glutamate and GABA receptor antagonists on nicotine-induced neurotransmitter changes in cognitive areas. | Fallon, S., et al. 2007. Neurochem Res. 32: 535-53. PMID: 16909314
- Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugs. | Bespalov, A., et al. 2007. J Pharmacol Exp Ther. 320: 944-50. PMID: 17135347
- Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression. | Bespalov, AY., et al. 2008. Eur J Pharmacol. 592: 96-102. PMID: 18634781
- Postsynaptic and presynaptic group II metabotropic glutamate receptor activation reduces neuronal excitability in rat midline paraventricular thalamic nucleus. | Hermes, ML. and Renaud, LP. 2011. J Pharmacol Exp Ther. 336: 840-9. PMID: 21139059
- NR2B-subunit dependent facilitation of long-term potentiation in primary visual cortex following visual discrimination training of adult rats. | Gagolewicz, PJ. and Dringenberg, HC. 2011. Eur J Neurosci. 34: 1222-9. PMID: 21895803
- mTOR activation is required for the antidepressant effects of mGluR₂/₃ blockade. | Dwyer, JM., et al. 2012. Int J Neuropsychopharmacol. 15: 429-34. PMID: 22114864
- Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. | Mahler, SV., et al. 2014. Addict Biol. 19: 49-60. PMID: 23017017
- Transient Adenosine Release Is Modulated by NMDA and GABAB Receptors. | Nguyen, MD., et al. 2017. ACS Chem Neurosci. 8: 376-385. PMID: 28071892
Inhibitor of:
dendrin, GABAB R2, GluR-δ2, GPR135, Grid2ip, mGluR-2, mGluR-3, mGluR-6, mGluR-7, NGL-1, NgR3, nyctalopin, Olfr720, Olfr748, Olfr749, Olfr750, PLA2G4B, PSD2, SAPAP4, SLITRK6, Snap91, TMEM132E, Vmn2r48, Vmn2r51, and Vmn2r57.Activator of:
mGLuR-8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 341495, 1 mg | sc-361244 | 1 mg | $87.00 | |||
LY 341495, 10 mg | sc-361244A | 10 mg | $219.00 |