Olfr739 Activators
Olfr739 is a member of the olfactory receptor family, specifically a G-protein coupled receptor (GPCR). GPCRs are known for their critical roles in various physiological processes, including the detection of molecules in the environment and the initiation of a cascade of intracellular events leading to a cellular response. Olfr739, like other olfactory receptors, is involved in the detection of specific chemical compounds, leading to signal transduction pathways that result in olfactory perception. The functionality of Olfr739, as with other GPCRs, is tightly regulated by its ability to respond to specific ligands and undergo conformational changes that initiate downstream signaling.
The mechanisms of activation for GPCRs like Olfr739 generally involve the binding of specific ligands to the receptor, which triggers a conformational change in the receptor protein. This change then activates an associated G-protein, leading to the production of second messengers such as cyclic AMP (cAMP) or inositol triphosphate (IP3). These messengers further propagate the signal within the cell, leading to various cellular responses. For Olfr739, the activation is likely to be influenced by ligands specific to olfactory signaling, but as a GPCR, it can also be modulated by changes in the levels of intracellular signaling molecules like cAMP, cGMP, and calcium ions. Therefore, chemicals that influence these pathways, either through direct interaction with the receptor or indirectly by modulating the levels of these signaling molecules, can potentially activate Olfr739. The chemicals listed above, such as cinacalcet, forskolin, and sildenafil, although not traditional olfactory ligands, can affect the intracellular environment in a manner that promotes the activation of Olfr739, highlighting the intricate and interconnected nature of GPCR signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, a labdane diterpene, is known for its ability to activate adenylate cyclase, leading to increased levels of cyclic AMP (cAMP). As Olfr739 is a G-protein coupled receptor (GPCR) that can be influenced by cAMP levels, forskolin's action indirectly promotes the activation of Olfr739. The elevated cAMP levels enhance the GPCR-mediated signaling pathways, thus functionally activating Olfr739. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Olfr739, being a GPCR, can be influenced by changes in calcium levels. The elevated intracellular calcium caused by ionomycin can activate Olfr739 through a mechanism involving calcium-mediated signaling pathways, which are critical in GPCR activation processes. | ||||||
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $250.00 | 1 | |
Pilocarpine, a muscarinic acetylcholine receptor agonist, can activate Olfr739 indirectly. It functions by stimulating muscarinic receptors, which share signaling pathways with Olfr739. This activation leads to changes in intracellular second messengers like IP3 and DAG, which can influence Olfr739's activation state due to the interconnected nature of GPCR signaling networks. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a non-selective beta-adrenergic agonist, activates Olfr739 indirectly through the stimulation of beta-adrenergic receptors. This activation results in increased cAMP levels, which is a common downstream effect in GPCR pathways. The enhanced cAMP levels in turn can lead to the activation of Olfr739, given its nature as a GPCR responsive to changes in cellular signaling molecules. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K 8644, a calcium channel agonist, leads to increased calcium influx. This alteration in intracellular calcium levels can activate Olfr739, as it is a GPCR that can be modulated by calcium-dependent signaling pathways. The calcium influx induced by Bay K 8644 thus facilitates the activation of Olfr739 through a mechanism linked to calcium signaling. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its action on histamine receptors, particularly H1 and H2, can indirectly activate Olfr739. As a GPCR, Olfr739's activity can be modulated by the downstream effects of histamine receptor activation, which includes changes in intracellular cAMP levels and calcium signaling, both pivotal in GPCR activation. | ||||||
Oxytocin acetate salt | 50-56-6 | sc-279938 sc-279938A sc-279938B sc-279938C sc-279938D sc-279938E | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $59.00 $176.00 $330.00 $650.00 $950.00 $1800.00 | 4 | |
Oxytocin, a hormone and neuropeptide, activates its receptors, which are GPCRs, leading to changes in intracellular calcium and cAMP levels. These changes can indirectly influence the activation of Olfr739, as alterations in these signaling molecules can modulate the activity of various GPCRs, including Olfr739. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Vardenafil, a PDE5 inhibitor like sildenafil, increases cAMP and cGMP levels in cells by inhibiting their degradation. The resultant increase in these cyclic nucleotides can indirectly activate Olfr739, a GPCR, by enhancing signaling pathways that involve cAMP and cGMP, key modulators of GPCR activity. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $120.00 $275.00 $380.00 $670.00 $1400.00 $3000.00 | 12 | |
Carbachol, a cholinergic agonist, activates muscarinic and nicotinic acetylcholine receptors. This activation influences intracellular signaling pathways related to calcium and cAMP, which can indirectly lead to the activation of Olfr739. The cross-talk between cholinergic and GPCR signaling pathways facilitates the activation of Olfr739 through these intracellular changes. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine, acting primarily on alpha and beta adrenergic receptors, influences cAMP levels and calcium signaling. As Olfr739 is a GPCR, these changes can indirectly activate it. The modulation of cAMP and calcium signaling by norepinephrine, therefore, can lead to the functional activation of Olfr739 through interconnected GPCR pathways. | ||||||