Olfr728 Inhibitors
Olfr728, a member of the olfactory receptor family 4 subfamily K (OR4K), plays a pivotal role in the sensory perception of odors in Mus musculus (house mouse). This receptor belongs to the large family of G-protein-coupled receptors (GPCRs) characterized by a distinctive 7-transmembrane domain structure, akin to many neurotransmitter and hormone receptors. The function of Olfr728 is to interact with odorant molecules present in the nasal cavity, thereby initiating a cascade of events leading to the perception of various scents. The primary role of Olfr728 is to recognize odorant molecules and transduce signals through G-protein-mediated pathways, culminating in the perception of odors. Inhibition of Olfr728 can be achieved through various mechanisms, including both direct and indirect methods.
Direct inhibitors, such as Cimetidine, act by specifically targeting the receptor and obstructing the binding of odorant molecules. This direct interference disrupts the initiation of neuronal responses that underlie the perception of smells. On the other hand, indirect inhibitors, such as Amlodipine and Tetrodotoxin, modulate cellular processes and signaling pathways that impact Olfr728's functionality. For instance, Amlodipine serves as a calcium channel blocker, influencing calcium influx and subsequently affecting downstream signaling cascades, ultimately leading to a diminished ability to perceive odorants. In conclusion, Olfr728 is a vital component of the olfactory system in house mice, responsible for detecting and translating odorant signals into sensory perception. The inhibition of Olfr728 can be accomplished through various chemical compounds, each with its unique mechanism of action. These inhibitors provide valuable insights into the intricate processes involved in olfactory perception, shedding light on the fundamental physiology of sensory perception in rodents.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Amlodipine is an indirect inhibitor that acts as a calcium channel blocker, influencing calcium influx and potentially affecting the downstream signaling cascade of Olfr728, leading to reduced functionality in perceiving odorants. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine is a direct inhibitor of Olfr728, specifically targeting the receptor and preventing the binding of odorant molecules. This inhibition disrupts the initiation of neuronal responses responsible for the perception of smells. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF 96365 is an indirect inhibitor that disrupts the shared 7-transmembrane domain structure of GPCRs, including Olfr728. It impairs the receptor's structural integrity, leading to compromised odorant recognition and inhibited G protein-mediated signaling. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is an indirect inhibitor that acts as a calcium channel blocker, influencing calcium influx and affecting the downstream signaling cascade of Olfr728. This leads to reduced functionality in perceiving odorants. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin (PTX) is an indirect inhibitor that interferes with the GPCR signaling pathway. PTX modifies G-proteins, disrupting downstream signaling from Olfr728, ultimately impairing the perception of odorants. | ||||||
Scopolamine | 51-34-3 | sc-473216 sc-473216A sc-473216B | 100 mg 500 mg 1 g | $172.00 $506.00 $786.00 | 2 | |
Scopolamine is an indirect inhibitor that targets muscarinic acetylcholine receptors, affecting neurotransmitter signaling and potentially altering neuronal responses to odorants through cross-talk with Olfr728. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $51.00 $131.00 | ||
Lidocaine is an indirect inhibitor that blocks sodium channels, influencing neuronal excitability and potentially modulating Olfr728's responses to odorants. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an indirect inhibitor that influences the calcineurin-NFAT signaling pathway. By inhibiting calcineurin, it indirectly affects Olfr728's function, reducing the perception of odors. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine is an indirect inhibitor that modulates oxidative stress pathways. It reduces oxidative stress, which can influence the neuronal response to odorants mediated by Olfr728. | ||||||