Olfr727 Inhibitors
Olfr727, a member of the olfactory receptor family 4, serves as a fundamental component in the sensory perception of smells in Mus musculus (house mouse). It belongs to the extensive family of G-protein-coupled receptors (GPCRs) characterized by a 7-transmembrane domain structure. This structural feature equips Olfr727 with the ability to interact with odorant molecules in the nasal cavity, initiating a series of events that ultimately result in the perception of various scents. The primary function of Olfr727 is to recognize and transduce signals from odorant molecules, which is essential for the perception of smells. Inhibition of Olfr727 can be achieved through both direct and indirect mechanisms. Direct inhibitors, such as Cimetidine, specifically target the receptor and hinder the binding of odorant molecules, thereby disrupting the initiation of neuronal responses responsible for perceiving smells.
Indirect inhibitors, including SKF 96365, Verapamil, and others, act on signaling pathways and cellular processes related to GPCRs. For instance, Verapamil serves as a calcium channel blocker, influencing calcium influx and affecting the downstream signaling cascade of Olfr727, ultimately leading to a reduced ability to perceive odorants. In summary, Olfr727 is a crucial component of the olfactory system in house mice, facilitating the recognition and perception of various odors. The inhibition of Olfr727 can be accomplished through a variety of chemical compounds, each with its distinct mechanism of action. These inhibitors contribute to our understanding of the intricate processes involved in olfactory perception, shedding light on the physiological intricacies of sensory perception in rodents.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine is a direct inhibitor of Olfr727, specifically targeting the receptor and preventing the binding of odorant molecules. This inhibition disrupts the initiation of neuronal responses responsible for the perception of smells. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF 96365 is an indirect inhibitor that disrupts the shared 7-transmembrane domain structure of GPCRs, including Olfr727. It impairs the receptor's structural integrity, leading to compromised odorant recognition and inhibited G protein-mediated signaling. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is an indirect inhibitor that acts as a calcium channel blocker, influencing calcium influx and affecting the downstream signaling cascade of Olfr727. This leads to reduced functionality in perceiving odorants. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin (PTX) is an indirect inhibitor that interferes with the GPCR signaling pathway. PTX modifies G-proteins, disrupting downstream signaling from Olfr727, ultimately impairing the perception of odorants. | ||||||
Scopolamine | 51-34-3 | sc-473216 sc-473216A sc-473216B | 100 mg 500 mg 1 g | $172.00 $506.00 $786.00 | 2 | |
Scopolamine is an indirect inhibitor that targets muscarinic acetylcholine receptors, affecting neurotransmitter signaling and potentially altering neuronal responses to odorants through cross-talk with Olfr727. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $51.00 $131.00 | ||
Lidocaine is an indirect inhibitor that blocks sodium channels, influencing neuronal excitability and potentially modulating Olfr727's responses to odorants. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an indirect inhibitor that influences the calcineurin-NFAT signaling pathway. By inhibiting calcineurin, it indirectly affects Olfr727's function, reducing the perception of odors. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine is an indirect inhibitor that modulates oxidative stress pathways. It reduces oxidative stress, which can influence the neuronal response to odorants mediated by Olfr727. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an indirect inhibitor that affects calcium signaling in neurons, modulating intracellular calcium levels and indirectly influencing Olfr727's function in transducing odorant signals by altering calcium-dependent processes in olfactory neurons. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is an indirect inhibitor that acts on adrenergic receptors, potentially influencing the sympathetic nervous system's impact on olfactory perception and Olfr727's responses to odorants. | ||||||