Olfr697 Inhibitors
Olfr697, also known as Olfactory Receptor Family 2 Subfamily AG Member 15, is a crucial component of the olfactory system in Mus musculus (house mouse). It belongs to the family of olfactory receptors, which play a pivotal role in the detection and initial processing of odorant molecules in the nasal passages. These olfactory receptors are a part of the G-protein-coupled receptor (GPCR) superfamily, characterized by a 7-transmembrane domain structure, shared with other neurotransmitter and hormone receptors. Olfr697, like its counterparts, is responsible for recognizing odorants and initiating signaling cascades mediated by G proteins, ultimately leading to the perception of smell. The olfactory receptor gene family is the most extensive in the genome, and the nomenclature assigned to these genes and proteins in Mus musculus is unique to this organism.
Inhibition of Olfr697 presents challenges, primarily due to its role in signal transduction rather than conventional enzymatic or structural functions. As a result, the chemical inhibition of Olfr697 typically involves indirect mechanisms that target the intricate intracellular signaling pathways associated with olfaction. A variety of chemicals, including those modulating cAMP, MEK/ERK, JNK, JAK kinases, AKT, Wnt, NF-κB, and GPCR desensitization pathways, can indirectly influence Olfr697. These chemicals exert their effects by disrupting downstream events required for proper olfactory receptor gene expression and function. In conclusion, Olfr697 plays a vital role in the house mouse's ability to detect and discriminate odors, contributing to their sensory perception. Inhibiting Olfr697 involves the modulation of complex signaling pathways related to olfaction. While direct chemical inhibitors may be elusive, understanding the potential indirect inhibitors and their effects on olfactory pathways enhances our understanding of sensory biology. Further research and experimental validation are necessary to elucidate the precise mechanisms of Olfr697 inhibition and their implications in the field of olfaction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 (PDE4) inhibitor, indirectly impacting Olfr697 by elevating intracellular cAMP levels in olfactory neurons. Increased cAMP enhances olfactory signal transduction, thereby influencing Olfr697 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK/ERK pathway inhibitor, indirectly affecting Olfr697. By blocking this pathway, it disrupts the downstream signaling events that regulate olfactory receptor gene expression, leading to inhibition of Olfr697. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a specific JNK inhibitor, indirectly affecting Olfr697 by interfering with the JNK signaling pathway involved in olfactory signal transduction. Inhibition of JNK disrupts the downstream events crucial for olfactory receptor function. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib inhibits JAK kinases, indirectly influencing Olfr697 expression by disrupting downstream events essential for proper olfactory receptor function. JAK kinases are involved in olfactory receptor signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3-kinase inhibitor that impacts the AKT pathway in olfactory neurons. By inhibiting this pathway, it indirectly affects Olfr697 expression, as the AKT pathway regulates downstream events related to olfactory receptor gene expression. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939 is a tankyrase inhibitor that modulates the Wnt pathway, indirectly affecting Olfr697. By disrupting the Wnt pathway, it interferes with cellular processes necessary for proper olfactory receptor function and gene expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an NF-κB inhibitor, indirectly suppressing Olfr697. NF-κB is involved in regulating olfactory receptor function and gene expression, and its inhibition disrupts these processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels in olfactory neurons. This elevation in cAMP indirectly upregulates Olfr697 expression by enhancing odorant signal transduction through the cAMP pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3-kinase inhibitor that impacts the PLC-IP3 pathway in olfactory neurons. By inhibiting this pathway, it indirectly influences Olfr697 by disrupting the intracellular signaling processes required for proper olfactory receptor function. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 is a JAK2 inhibitor, indirectly influencing Olfr697 expression by disrupting downstream events essential for proper olfactory receptor function. JAK2 kinases are involved in olfactory receptor signaling pathways. | ||||||