Olfr648 Inhibitors
Olfr648, an olfactory receptor, plays a pivotal role in the complex process of olfaction, contributing to the detection and discrimination of diverse odorants. As a G protein-coupled receptor (GPCR) expressed on the surface of olfactory sensory neurons, Olfr648 is integral to the transduction of odor signals into neural impulses. Upon binding to specific odor molecules, Olfr648 initiates a cascade of intracellular events, activating second messenger systems and ultimately leading to the perception of distinct smells. The precise ligand-receptor interactions and the subsequent cellular responses orchestrated by Olfr648 are fundamental to the intricacies of olfactory perception.
Inhibition of Olfr648 involves the targeted modulation of key cellular pathways and processes associated with olfactory signal transduction. Various inhibitors act through diverse mechanisms, such as disrupting intracellular pH regulation by inhibiting V-ATPase, altering cellular respiration through mitochondrial complex I inhibition, and modulating critical signaling pathways like PI3K/Akt, MAPK, and Wnt. These indirect inhibitors impact Olfr648 function by influencing downstream signaling cascades or cellular processes that are interconnected with olfactory signal transduction. Calcium channel inhibitors and chelators, for instance, regulate intracellular calcium levels, a crucial factor in olfactory receptor activation. The comprehensive array of inhibitors outlined in the table reflects the multifaceted nature of Olfr648 inhibition, targeting specific cellular components and signaling pathways to intricately modulate the olfactory response. Understanding these inhibition mechanisms is pivotal in unraveling the complexities of olfactory perception at the molecular level.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 inhibits V-ATPase, disrupting intracellular pH regulation and vesicular trafficking, which indirectly influences Olfr648 function by affecting endosomal acidification. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that modulates the PI3K/Akt signaling pathway, indirectly impacting Olfr648 function by interfering with downstream signaling cascades involved in olfactory perception. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that affects the MAPK pathway, influencing Olfr648 indirectly. The inhibition of specific MAP kinases alters the signaling network associated with olfactory receptor function. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits mitochondrial complex I, disrupting cellular respiration and influencing Olfr648 function by modulating the energy balance within the cell, ultimately impacting olfactory signal transduction. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor that influences Olfr648 indirectly by modulating the p38 MAP kinase pathway, altering the signaling dynamics associated with olfactory perception. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $65.00 $162.00 $650.00 $2550.00 | 109 | |
Concanamycin A inhibits V-ATPase, disrupting intracellular pH regulation and vesicular trafficking, indirectly influencing Olfr648 function by affecting endosomal acidification. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel inhibitor that indirectly affects Olfr648 function by modulating intracellular calcium levels, influencing the signaling pathways associated with olfactory signal transduction. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that affects the MAPK pathway, influencing Olfr648 indirectly. The inhibition of specific MAP kinases alters the signaling network associated with olfactory receptor function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor that modulates the PI3K/Akt signaling pathway, indirectly impacting Olfr648 function by interfering with downstream signaling cascades involved in olfactory perception. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a calcium chelator that indirectly influences Olfr648 function by regulating intracellular calcium levels, impacting the signaling pathways associated with olfactory signal transduction. | ||||||