Olfr599 Inhibitors
Olfr599, an olfactory receptor, stands as a crucial player in cellular processes, primarily dedicated to olfactory perception by transducing signals in response to diverse olfactory stimuli. Beyond its role in olfaction, Olfr599 is intricately connected to several signaling pathways, notably the MAPK, PI3K/Akt, and JNK pathways, which collectively govern fundamental cellular functions such as survival, proliferation, and stress responses. Functioning as a sensory receptor, Olfr599 is finely tuned to detect and interpret olfactory cues, contributing to the intricate network of signaling events that shape cellular behavior.
The inhibition of Olfr599 involves a sophisticated interplay of chemical inhibitors that act either directly on the receptor or indirectly by targeting key components within its associated signaling pathways. Direct inhibitors disrupt specific activation events crucial for Olfr599 function, thereby impeding downstream signal transduction cascades that are integral to its cellular impact. Additionally, indirect inhibitors modulate related pathways, including TGF-β, FGFR, and EGFR signaling, intricately influencing Olfr599 function by altering cellular responses associated with differentiation, migration, and gene expression regulation. This nuanced approach to Olfr599 inhibition unveils its broader cellular impact beyond olfactory perception, providing valuable insights into the receptor's intricate involvement in shaping cellular processes. Understanding the mechanisms of Olfr599 inhibition not only enhances our comprehension of olfactory signal transduction but also sheds light on its multifaceted cellular role, fostering further exploration in the realms of cellular and molecular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine, a broad-spectrum kinase inhibitor, directly inhibits Olfr599 by targeting multiple kinases involved in its activation. This leads to disruption of downstream signaling cascades, notably affecting the MAPK and PI3K pathways, critical for Olfr599 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, directly hinders Olfr599 by obstructing the PI3K/Akt pathway. This interference negatively impacts Olfr599 function by disrupting downstream signaling events, particularly influencing the regulation of cellular survival and proliferation processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, directly influences Olfr599 by blocking p38 MAPK activation. This interruption hampers Olfr599-associated signal transduction pathways, including the JNK pathway, thereby leading to the inhibition of Olfr599 function at the cellular level. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126, a MEK1 and MEK2 inhibitor, directly targets Olfr599 by disrupting the MAPK/ERK pathway. This interference inhibits Olfr599 activation and downstream transcriptional events, specifically hindering its role in modulating gene expression related to cellular processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, directly inhibits Olfr599 by targeting the JNK signaling pathway. This interference disrupts key events in Olfr599 activation, affecting downstream processes involved in cellular response to stress and influencing Olfr599's regulatory role in these pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin acts as a potent inhibitor by binding irreversibly to PI3K, a key player in Olfr599 signaling. By obstructing PI3K activity, Wortmannin disrupts the downstream Akt pathway, thereby indirectly inhibiting Olfr599 and impairing its functional role in cellular processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a selective MEK inhibitor, directly inhibits Olfr599 by disrupting the MAPK/ERK pathway. This interference impedes Olfr599 activation and downstream transcriptional events, affecting its role in regulating gene expression linked to cellular processes. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542, a TGF-β receptor inhibitor, indirectly inhibits Olfr599 by disrupting the TGF-β signaling pathway. This interference alters downstream events, influencing Olfr599 function by modulating cellular responses to TGF-β and affecting processes related to cell differentiation and migration. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib, an EGFR kinase inhibitor, directly targets Olfr599 by inhibiting EGFR-mediated phosphorylation events essential for its activation. This inhibition disrupts downstream signaling cascades, including the Ras/Raf/MEK/ERK pathway, crucial for Olfr599 functionality. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074, an FGFR inhibitor, directly targets Olfr599 by inhibiting FGFR-mediated signaling. This inhibition disrupts downstream pathways, including the Ras/Raf/MEK/ERK pathway, crucial for Olfr599 functionality, thus influencing its role in modulating gene expression linked to cellular processes. | ||||||