Olfr586 Inhibitors
Olfr586, situated within the olfactory epithelium, plays a pivotal role in the complex process of olfactory signal transduction. As a member of the olfactory receptor family, Olfr586 serves as a molecular sensor dedicated to detecting specific odorants within the environment. When engaged by odorant molecules, Olfr586 initiates a cascade of intracellular events, ultimately resulting in the generation and transmission of olfactory signals. This intricate process is integral to our ability to perceive and differentiate a myriad of scents, contributing significantly to the intricacies of the human sense of smell.
The general mechanisms of inhibiting Olfr586 involve the modulation of specific intracellular signaling pathways associated with its function. Inhibitors targeting pathways such as PI3K/AKT, TGF-β, MAPK, AMPK, JNK, and NF-κB disrupt downstream processes critical for olfactory signal transduction. For instance, modulation of the PI3K/AKT pathway influences Olfr586 indirectly by altering cellular events essential for olfactory signal transduction. Similarly, inhibition of the TGF-β pathway disrupts the cascade associated with Olfr586, influencing cellular processes related to olfactory signaling. These inhibitors act as intricate tools to unravel the intricacies of olfactory receptor function, providing valuable insights into the molecular mechanisms that govern olfaction. By understanding and manipulating these pathways, researchers gain a deeper understanding of olfactory processes at the molecular level, contributing to the broader knowledge of sensory perception.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Phosphoinositide 3-kinase (PI3K) inhibitor influencing intracellular signaling cascades. Its impact on PI3K pathways indirectly inhibits Olfr586 by disrupting downstream processes essential for olfactory signal transduction. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β receptor inhibitor affecting the TGF-β signaling pathway. Indirectly inhibits Olfr586 by disrupting the TGF-β cascade, altering cellular processes associated with olfactory signal transduction. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Phosphoinositide 3-kinase (PI3K) inhibitor affecting the PI3K/AKT signaling pathway. Indirectly inhibits Olfr586 by disrupting downstream processes crucial for olfactory signal transduction. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Selective MEK inhibitor impacting the MAPK pathway. Indirectly inhibits Olfr586 by disrupting the MAPK cascade, altering cellular processes critical for olfactory signal transduction. | ||||||
GDC-0879 | 905281-76-7 | sc-364497 | 5 mg | $225.00 | ||
B-Raf inhibitor affecting the MAPK pathway. Its impact on this pathway indirectly inhibits Olfr586, disrupting downstream signaling cascades crucial for olfactory signal transduction. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
AMP-activated protein kinase (AMPK) activator influencing energy homeostasis. Indirectly inhibits Olfr586 by modulating AMPK-mediated pathways, altering cellular metabolic processes that influence olfactory signal transduction. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
c-Jun N-terminal kinase (JNK) inhibitor impacting stress-related signaling pathways. Its action on JNK pathways indirectly inhibits Olfr586, disrupting cellular responses associated with stress signaling in the olfactory system. | ||||||
AZD5363 | 1143532-39-1 | sc-503190 | 5 mg | $309.00 | ||
AKT kinase inhibitor influencing the PI3K/AKT signaling pathway. Indirectly inhibits Olfr586 by modulating AKT-mediated processes, altering cellular events crucial for olfactory signal transduction. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 mitogen-activated protein kinase (MAPK) inhibitor disrupting inflammatory signaling pathways. Its impact on MAPK cascades indirectly inhibits Olfr586, as the receptor is sensitive to alterations in inflammatory signals in the olfactory system. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
MEK1/2 inhibitor targeting the MAPK pathway. Its influence on this pathway indirectly inhibits Olfr586 by disrupting downstream signaling cascades crucial for olfactory signal transduction. | ||||||