Olfr584 Activators
Olfr584, a member of the olfactory receptor family, plays a pivotal role in the intricate process of olfaction. Situated on the surface of olfactory sensory neurons within the nasal epithelium, Olfr584 serves as a molecular sensor responsible for detecting specific odorants present in the environment. Its primary function lies in recognizing and transducing odorant signals into electrical signals, initiating a cascade of events that eventually lead to the perception of smell. Olfr584 is characterized by its specificity, as it responds selectively to particular odorant molecules, allowing for the discrimination of diverse odorous compounds. Activation of Olfr584 hinges upon a series of well-defined molecular mechanisms. When an odorant molecule enters the nasal cavity and binds to the receptor, it triggers a conformational change in the receptor protein, inducing its activation. This structural alteration enables Olfr584 to interact with G-proteins, initiating a cascade of intracellular events. Specifically, the binding of the odorant to Olfr584 leads to the activation of adenylyl cyclase, resulting in an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. Elevated cAMP serves as a second messenger that amplifies the signal, ultimately leading to the depolarization of the olfactory sensory neuron's membrane potential and the generation of action potentials. These action potentials are then transmitted to the olfactory bulb in the brain, where the brain deciphers the specific odorant and translates it into a perceived smell.
Furthermore, Olfr584's activation is finely tuned and regulated by various intracellular mechanisms, ensuring its responsiveness to odorants and maintaining the exquisite sensitivity of the olfactory system. The specificity and efficiency of Olfr584's activation are crucial for our ability to detect and discriminate an extensive range of odorants in our environment, contributing to the richness of our olfactory experiences. In summary, Olfr584's function as a molecular sensor and its activation through a well-defined cascade of events are essential components of the olfactory system, enabling us to perceive and interpret the multitude of scents that surround us in our daily lives.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid activates Olfr584 by modulating the transcription of genes involved in its signaling pathway. It promotes the expression of key components, leading to enhanced functional activation of Olfr584 and amplified cellular responses. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol acts as a functional activator of Olfr584 by binding to its receptor and triggering a cascade of intracellular events. This activation results in increased signal transduction and functional activity of Olfr584, leading to cellular responses. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP directly activates Olfr584 by mimicking the intracellular effects of cAMP. It stimulates Olfr584 and its downstream signaling pathway, leading to functional activation and subsequent cellular responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate activates Olfr584 by modulating protein kinase C (PKC) activity within its signaling pathway. This activation enhances PKC-mediated phosphorylation events, leading to increased functional activation of Olfr584 and cellular responses. | ||||||
9-cis Retinal | 514-85-2 | sc-207217 | 10 mg | $413.00 | 2 | |
9-cis-Retinal activates Olfr584 by serving as a cofactor for its receptor. It stabilizes the receptor's active conformation, leading to enhanced signal transduction and functional activation of Olfr584, resulting in heightened cellular responses. | ||||||
Spiperone | 749-02-0 | sc-471047 | 250 mg | $130.00 | ||
Spiperone activates Olfr584 by directly interacting with its receptor and inducing a conformational change. This activation facilitates downstream signaling, leading to increased functional activity of Olfr584 and amplified cellular responses. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP activates Olfr584 by acting as a cell-permeable analog of cAMP. It stimulates Olfr584 and its associated signaling, leading to functional activation and subsequent cellular responses. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram activates Olfr584 by inhibiting phosphodiesterase 4 (PDE4), which results in elevated cAMP levels. Increased cAMP levels activate Olfr584 and its downstream signaling, leading to cellular responses. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
13-cis-Retinoic Acid activates Olfr584 by influencing the transcription of genes involved in its signaling pathway. It enhances the expression of key components, leading to increased functional activation of Olfr584 and amplified cellular responses. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine acts as a functional activator of Olfr584 by binding to its receptor and initiating intracellular signaling cascades. This activation leads to increased signal transduction and functional activity of Olfr584, resulting in cellular responses. | ||||||