Olfr557 Inhibitors
Olfr557, an integral member of the olfactory receptor family, is a G protein-coupled receptor (GPCR) positioned on the surface of olfactory sensory neurons within the nasal epithelium. Serving as a molecular sensor, Olfr557 plays a crucial role in the process of olfaction by responding to a diverse range of odorant molecules. Upon binding with specific odorants, Olfr557 initiates intricate intracellular signaling cascades, ultimately leading to the generation of neuronal signals transmitted to the brain. This orchestrated process is fundamental for the organism's environmental perception and adaptive responses.
The inhibition of Olfr557 involves a sophisticated interplay with key signaling pathways intricately linked to its regulation. The inhibitors outlined in the table act either directly or indirectly, targeting pathways such as AMPK, PI3K/Akt, NF-κB, JNK, p38 MAPK, MEK, JAK/STAT, TGF-β, and mTOR. These pathways are integral components of the intricate network governing Olfr557 expression and functional outcomes. The general mechanisms of inhibition aim to disrupt the delicate balance within these pathways, consequently influencing Olfr557 activity. This comprehensive understanding provides valuable insights for scientific exploration into the complex mechanisms underlying olfactory receptor modulation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), indirectly inhibiting Olfr557. By activating AMPK, it modulates cellular energy status, impacting pathways critical for Olfr557 regulation. | ||||||
CAL-101 | 870281-82-6 | sc-364453 | 10 mg | $189.00 | 4 | |
CAL-101 is a selective inhibitor of PI3Kδ, influencing the PI3K/Akt pathway. Its indirect effect on Olfr557 is exerted through the disruption of the PI3K/Akt signaling cascade crucial for Olfr557 modulation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation. Its indirect impact on Olfr557 occurs through alterations in cellular responses regulated by the NF-κB pathway, which is involved in Olfr557 modulation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, a component of the JNK signaling pathway. By disrupting this pathway, it indirectly impacts Olfr557, which is responsive to alterations in JNK-mediated cellular responses. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a potent inhibitor of p38 MAPK. Its action on p38 MAPK indirectly influences Olfr557 by altering the cellular environment and signaling cascades that impact Olfr557 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K/Akt signaling, indirectly affecting Olfr557. The PI3K/Akt pathway plays a crucial role in Olfr557 regulation, making this inhibitor an effective indirect modulator. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective MEK inhibitor, blocking the MAPK pathway. Its indirect effect on Olfr557 is exerted through the modulation of the MAPK signaling cascade, crucial for Olfr557 regulation. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib inhibits JAK1 and JAK2. By targeting JAK/STAT signaling, it indirectly influences Olfr557, disrupting the pathway linked to Olfr557 regulation. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
MK-2206 is a selective Akt inhibitor. Its indirect impact on Olfr557 occurs through the disruption of the PI3K/Akt pathway, crucial for the regulation of Olfr557. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a selective inhibitor of TGF-β receptor, influencing TGF-β signaling pathways. Indirectly, it modulates Olfr557, as TGF-β pathways interact with the regulatory mechanisms of Olfr557. | ||||||