Olfr552 Inhibitors
Olfr552 is a G protein-coupled receptor (GPCR) that plays a crucial role in cellular signaling. Its function is intricately linked to various signaling pathways, including the MAPK, PI3K/Akt, TGF-β, JNK, mTOR, AhR, and NF-κB pathways. These pathways regulate Olfr552 expression and activity, making them potential targets for inhibition.
The inhibition of Olfr552 involves targeting specific components of these pathways. Staurosporine directly inhibits Olfr552 through its broad-spectrum kinase inhibition. Additionally, inhibitors like U0126, LY294002, SB203580, and Wortmannin indirectly modulate Olfr552 by disrupting key signaling cascades. SB431542 influences Olfr552 through its selective inhibition of TGF-β receptor, while SP600125 and PD98059 affect Olfr552 by targeting the JNK and MAPK pathways, respectively. Rapamycin and SP2509 exert indirect inhibition by targeting mTOR and AhR pathways. JSH-23 inhibits NF-κB activation, impacting Olfr552 via alterations in NF-κB-regulated responses. LY2874455 indirectly influences Olfr552 by inhibiting IGF1R/IR, disrupting pathways associated with Olfr552 regulation. In summary, Olfr552 inhibition involves a strategic approach targeting multiple signaling pathways, either directly or indirectly, to modulate its expression and activity. This comprehensive understanding opens avenues for exploring chemical interventions that could potentially regulate Olfr552 function for scientific research purposes.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. It directly inhibits Olfr552 by targeting its kinase activity, disrupting essential cellular signaling pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2 in the MAPK pathway. By specifically blocking this pathway, it indirectly influences Olfr552, which is modulated by MAPK signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K/Akt signaling, indirectly affecting Olfr552. The PI3K/Akt pathway plays a crucial role in Olfr552 regulation, making this inhibitor an effective indirect modulator. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a potent inhibitor of p38 MAPK. Its action on p38 MAPK indirectly influences Olfr552 by altering the cellular environment and signaling cascades that impact Olfr552 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, disrupting the PI3K/Akt pathway. This disruption indirectly affects Olfr552, as its regulation is intricately linked to the activity of the PI3K/Akt signaling. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a selective inhibitor of TGF-β receptor, influencing TGF-β signaling pathways. Indirectly, it modulates Olfr552, as TGF-β pathways interact with the regulatory mechanisms of Olfr552. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, a component of the JNK signaling pathway. By disrupting this pathway, it indirectly impacts Olfr552, which is responsive to alterations in JNK-mediated cellular responses. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective MEK inhibitor, blocking the MAPK pathway. Its indirect effect on Olfr552 is exerted through the modulation of the MAPK signaling cascade, crucial for Olfr552 regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key player in cellular signaling. By modulating mTOR, it indirectly influences Olfr552, whose expression and function are intertwined with mTOR-regulated pathways. | ||||||
SP2509 | 1423715-09-6 | sc-492604 | 5 mg | $284.00 | ||
SP2509 is a selective inhibitor of the aryl hydrocarbon receptor (AhR). By affecting AhR signaling, it indirectly modulates Olfr552, which is responsive to alterations in the AhR-regulated pathways. | ||||||