Olfr54 Inhibitors
Olfr54, a member of the olfactory receptor family, serves as a crucial molecular entity in the olfactory system, contributing significantly to the detection and discrimination of specific odorants. This receptor plays a pivotal role in orchestrating olfactory signal transduction, initiating intricate cascades of events upon binding to its cognate ligands. Functionally, Olfr54 is essential for the nuanced interpretation of olfactory stimuli, enabling organisms to navigate and respond to their environment based on distinct smells.
The inhibition of Olfr54 involves a sophisticated interplay with various signaling pathways. The inhibitors presented here act either directly on Olfr54 or indirectly by influencing parallel pathways associated with its function. For instance, inhibitors like Ceritinib and U0126 directly target the ALK and MAPK pathways, respectively, disrupting Olfr54 activation by interfering with crucial protein-protein interactions and phosphorylation events. Indirect inhibitors like Wortmannin and SB-431542 modulate the PI3-kinase and TGF-beta pathways, respectively, altering the equilibrium of key molecules and suppressing Olfr54 activity indirectly by disrupting the interconnected signaling network. The diverse mechanisms employed by these inhibitors underscore the intricacies of Olfr54 inhibition, providing valuable insights into potential strategies for controlling olfactory signal transduction at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine | 1032900-25-6 | sc-505041 | 1 mg | $230.00 | ||
Inhibitor targeting the ALK pathway associated with Olfr54 activation. Modulates intracellular signaling by impeding ALK kinase activity, hindering downstream cascades crucial for Olfr54 function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
MEK inhibitor that inhibits the MAPK pathway. Alters SPRY4 expression, acting as a negative feedback regulator within this pathway and indirectly suppressing Olfr54 function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits the TGF-beta pathway influencing Olfr54 activation. Alters the equilibrium of key molecules, indirectly suppressing Olfr54 function by disrupting the interplay within the signaling network. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Potent inhibitor targeting the p38 MAP kinase pathway, disrupting Olfr54 activation. Interferes with phosphorylation events crucial for Olfr54 function, thereby hindering downstream signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3-kinase inhibitor selectively blocking a pathway associated with Olfr54 activation. Modulates cellular processes by impeding key intermediates, resulting in the suppression of Olfr54 activity. | ||||||
VX-11e | 896720-20-0 | sc-507301 | 10 mg | $180.00 | ||
JAK2 inhibitor affecting the JAK/STAT pathway linked to Olfr54. Modulates intracellular signaling by inhibiting JAK2 kinase activity, hindering downstream cascades crucial for Olfr54 function. | ||||||
Doramapimod | 285983-48-4 | sc-300502 sc-300502A sc-300502B | 25 mg 50 mg 100 mg | $149.00 $281.00 $459.00 | 2 | |
Selective p38 MAP kinase inhibitor disrupting the MAPK pathway associated with Olfr54 activation. Interferes with phosphorylation events crucial for Olfr54 function, hindering downstream signaling. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Src kinase inhibitor modulating the Src kinase pathway linked to Olfr54. Impedes Src kinase activity, altering phosphorylation events crucial for Olfr54 function and suppressing downstream signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Modulates the JNK pathway crucial for Olfr54 activation. Alters the phosphorylation status of critical proteins, indirectly suppressing Olfr54 function by disrupting the interconnected signaling network. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Disrupts Olfr54 activation by targeting the NF-kB pathway. Modulates the activity of upstream molecules, resulting in the indirect inhibition of Olfr54 through altered signaling. | ||||||