Olfr493 Inhibitors
Olfr493, a crucial member of the olfactory receptor protein family, plays a pivotal role in the intricate process of odorant perception within the olfactory system. As a G-protein-coupled receptor (GPCR), Olfr493 is situated in the sensory neurons of the nose and interacts with odorant molecules, initiating a series of events that culminate in a neuronal response and the perception of smell. The olfactory receptor proteins, including Olfr493, are characterized by a 7-transmembrane domain structure, resembling many neurotransmitter and hormone receptors. This structural similarity underscores their shared responsibility for recognizing odorants and facilitating G protein-mediated transduction of olfactory signals. Being part of the largest gene family in the genome, Olfr493's unique nomenclature highlights its independence from other organisms, emphasizing the diverse and complex nature of olfactory receptor genes and proteins.
The inhibition of Olfr493 involves a sophisticated interplay of diverse mechanisms, aiming to modulate its activity and subsequently impact the olfactory transduction process. Various inhibitors act on key components within intricate signaling pathways linked to olfactory transduction, such as the IP3 signaling pathway, cAMP signaling pathway, and MAPK pathway. These inhibitors disrupt crucial events downstream of Olfr493 activation, including calcium release, GPCR-mediated transduction, and phosphorylation cascades. By targeting these intricate processes, inhibitors indirectly suppress Olfr493, leading to altered neuronal responses and reduced perception of odorant stimuli. This intricate web of inhibitory mechanisms sheds light on the complexity of olfactory signal processing and provides valuable insights into potential strategies for modulating olfactory receptor function, contributing to a deeper understanding of the mechanisms governing odor perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $500.00 | 14 | |
Inhibits Olfr493 by blocking IP3 receptors, disrupting calcium release and downstream events crucial for proper olfactory transduction, leading to reduced perception of smell. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $336.00 $1642.00 | 20 | |
Targets PKC, impacting the cAMP signaling pathway and indirectly suppressing Olfr493 by disrupting GPCR-mediated transduction of olfactory signals, resulting in diminished smell perception. | ||||||
FR 900359 | 107530-18-7 | sc-507357 | 500 µg | $222.00 | ||
Blocks Gq proteins, inhibiting the IP3 signaling pathway and interfering with calcium release in olfactory transduction. This leads to reduced activation of Olfr493 and diminished odor perception. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Inhibits PKC, affecting the cAMP signaling pathway and indirectly suppressing Olfr493 by disrupting GPCR-mediated transduction of olfactory signals, diminishing the perception of smell. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
Blocks CaMKII, interfering with calcium signaling and indirectly inhibiting Olfr493 by disrupting downstream events crucial for proper olfactory transduction, reducing the perception of smell. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibits PI3-kinase, affecting intracellular signaling pathways associated with olfactory transduction. By indirectly suppressing Olfr493, it alters neuronal responses, diminishing odor perception. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Targets p38 MAPK, impacting the MAPK pathway and indirectly inhibiting Olfr493. This disruption alters downstream signaling, leading to reduced activation of the receptor and diminished smell perception. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Blocks Src family kinases, interfering with intracellular signaling cascades involved in olfactory transduction, and subsequently inhibiting Olfr493, leading to reduced perception of smell. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Targets Gβγ subunits, inhibiting the GPCR signaling pathway. Indirectly suppresses Olfr493, disrupting downstream events crucial for proper olfactory transduction and reducing the perception of smell. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
Inhibits CaMKII, disrupting calcium signaling and indirectly suppressing Olfr493 by interfering with downstream events crucial for proper olfactory transduction, reducing the perception of smell. | ||||||