Olfr47 Inhibitors
Olfr47, a prominent member of the olfactory receptor family, is instrumental in initiating neuronal responses crucial for the perception of odors. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Olfr47 shares structural characteristics with neurotransmitter and hormone receptors. Its primary function involves the recognition and G protein-mediated transduction of odorant signals within the nasal cavity, contributing significantly to the diversity of olfactory experiences.
The inhibition of Olfr47 entails a sophisticated interplay of various chemical inhibitors targeting specific cellular pathways pivotal for olfactory signal transduction. Compounds affecting muscarinic receptor activity, disrupting cAMP signaling, modulating PI3K-dependent events, interfering with calcium-dependent processes, and inhibiting MAPK and PKC pathways collectively contribute to Olfr47 inhibition. These intricate mechanisms highlight the depth of understanding required to unravel the complexities of olfactory receptor function and underscore the interplay of molecular events crucial for regulating Olfr47's role in olfactory perception. Exploring these mechanisms serves as a foundation for advancing our understanding of olfactory processes, unraveling the molecular intricacies governing the perception of diverse odors mediated by Olfr47 in this organism.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atropine | 51-55-8 | sc-252392 | 5 g | $200.00 | 2 | |
An antagonist of muscarinic acetylcholine receptors that hinders G protein-mediated signaling cascades associated with olfactory transduction. Atropine indirectly inhibits Olfr47 by disrupting muscarinic receptor activity, leading to impaired recognition and transduction of odorant signals within the olfactory system. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A phosphodiesterase 4 (PDE4) inhibitor that modulates cAMP signaling pathways involved in olfactory signal transduction. Rolipram indirectly inhibits Olfr47 by disrupting PDE4-dependent events crucial for proper G protein-mediated transduction of odorant signals, affecting the receptor's ability to initiate a neuronal response. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A phosphoinositide 3-kinase (PI3K) inhibitor that influences intracellular signaling pathways. This chemical indirectly inhibits Olfr47 by disrupting PI3K-dependent events, impairing the normal transduction of odorant signals and negatively impacting the G protein-mediated responses of the olfactory receptor. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $153.00 $600.00 | 27 | |
A calmodulin antagonist that interferes with calcium-calmodulin-dependent processes in olfactory signal transduction. Calmidazolium indirectly inhibits Olfr47 by disrupting calmodulin-dependent events crucial for proper G protein-mediated transduction of odorant signals, affecting the receptor's ability to initiate a neuronal response. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective MEK inhibitor that disrupts the MAPK pathway. This compound indirectly inhibits Olfr47 by interfering with MAPK-dependent events, negatively impacting the G protein-mediated transduction of odorant signals. The disruption occurs at the level of MEK, influencing downstream events crucial for olfactory perception. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
A sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) inhibitor that influences intracellular calcium levels. This chemical indirectly inhibits Olfr47 by disrupting calcium-dependent events, impairing the normal transduction of odorant signals and negatively impacting the G protein-mediated responses of the olfactory receptor. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A Src family kinase inhibitor that modulates Src-dependent processes in olfactory signal transduction. This compound indirectly inhibits Olfr47 by disrupting Src-dependent events crucial for proper G protein-mediated transduction of odorant signals, affecting the receptor's ability to initiate a neuronal response. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
A CaMKII inhibitor that modulates CaMKII-dependent processes in olfactory signal transduction. This chemical indirectly inhibits Olfr47 by interfering with calcium-calmodulin-dependent kinase II (CaMKII), disrupting downstream events crucial for G protein-mediated transduction of odorant signals. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $209.00 $352.00 | 3 | |
A protein kinase C (PKC) inhibitor that modulates PKC-dependent processes in olfactory signal transduction. This chemical indirectly inhibits Olfr47 by disrupting PKC-dependent events crucial for proper G protein-mediated transduction of odorant signals, affecting the receptor's ability to initiate a neuronal response. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective MEK inhibitor that disrupts the MAPK pathway. This compound indirectly inhibits Olfr47 by interfering with MAPK-dependent events, negatively impacting the G protein-mediated transduction of odorant signals. The disruption occurs at the level of MEK, influencing downstream events crucial for olfactory perception. | ||||||