Olfr466 Inhibitors
Olfr466, a pivotal member of the olfactory receptor family, plays a central role in the initiation of neuronal responses essential for the perception of smells. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Olfr466 shares structural similarities with neurotransmitter and hormone receptors. Its primary function involves the recognition and G protein-mediated transduction of odorant signals within the nasal cavity, contributing significantly to the diversity of olfactory experiences.
The inhibition of Olfr466 is orchestrated through a sophisticated array of interventions that intricately target specific cellular pathways crucial for olfactory signal transduction. Compounds affecting cAMP signaling, disrupting MAPK pathways, modulating ionotropic processes, inhibiting G proteins, interfering with calcium channels, and manipulating PKC signaling collectively contribute to Olfr466 inhibition. These intricate mechanisms showcase the depth of understanding required to decipher the complexities of olfactory receptor function and highlight the interplay of molecular events crucial for the regulation of Olfr466's role in olfactory perception. The exploration of these mechanisms serves as a foundation for advancing our understanding of olfactory processes, unraveling the molecular intricacies that govern the perception of diverse odors mediated by Olfr466 in this organism.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A phosphodiesterase 4 (PDE4) inhibitor that modulates the cAMP signaling pathway. By inhibiting PDE4 activity, it increases intracellular cAMP levels, negatively affecting the olfactory transduction process. This disruption hampers the G protein-mediated transduction of odorant signals by Olfr466. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An adenylyl cyclase activator that enhances cAMP production. Elevated cAMP levels interfere with the olfactory receptor signaling cascade by hyperactivating downstream components. This chemical indirectly inhibits Olfr466 by dysregulating the normal G protein-mediated transduction of odorant signals. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A mitogen-activated protein kinase (MAPK) inhibitor targeting the ERK pathway. This compound disrupts the downstream signaling events of Olfr466, influencing neuronal responses to odorant molecules by specifically targeting the MAPK pathway, indirectly inhibiting the G protein-coupled receptor function of Olfr466. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
An ion channel blocker that interferes with the normal ion flux associated with olfactory signal transduction. By disrupting the ionotropic processes, this chemical indirectly inhibits Olfr466, impairing its ability to initiate a neuronal response to odorant molecules. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
A G protein inhibitor that specifically targets the Gα subunit involved in olfactory signal transduction. This compound disrupts the G protein-mediated transduction process, leading to the indirect inhibition of Olfr466. The interference occurs at the molecular level, impacting the receptor's ability to recognize odorant signals. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
A calcium channel antagonist that interferes with intracellular calcium levels. By disrupting calcium-mediated signaling events, this chemical indirectly inhibits Olfr466, as calcium plays a crucial role in the modulation of olfactory receptor proteins. The disruption affects the receptor's ability to transduce odorant signals effectively. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
A protein kinase C (PKC) activator that modulates the PKC signaling pathway. This chemical indirectly inhibits Olfr466 by influencing downstream PKC-mediated events, disrupting the normal transduction of odorant signals. The altered phosphorylation events impair the receptor's ability to initiate a neuronal response to odorants. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
A microtubule-stabilizing agent that disrupts microtubule dynamics involved in intracellular transport. By affecting cellular processes related to olfactory signal transduction, this chemical indirectly inhibits Olfr466, influencing the receptor's ability to initiate a neuronal response to odorant molecules. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
A Raf-1 kinase inhibitor that targets the Raf-MEK-ERK pathway. This compound disrupts downstream signaling events associated with Olfr466, indirectly inhibiting the G protein-coupled receptor function. The interference occurs at the level of Raf-1 kinase, impacting the transduction of odorant signals. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
A CaMKII inhibitor that modulates CaMKII-dependent processes in olfactory signal transduction. This chemical indirectly inhibits Olfr466 by interfering with calcium-calmodulin-dependent kinase II (CaMKII), disrupting downstream events crucial for G protein-mediated transduction of odorant signals. | ||||||