Olfr452 Inhibitors
Olfr452, a key member of the olfactory receptor gene family, plays a crucial role in the intricate process of odorant signal transduction, ultimately leading to the perception of diverse smells. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Olfr452 is responsible for recognizing and transducing odorant signals through the mediation of G proteins. The singular coding-exon genes and independent nomenclature of Olfr452 highlight its uniqueness within the genome, contributing to the complexity of the olfactory sensory system.
Inhibition of Olfr452 involves a diverse array of direct and indirect mechanisms, each intricately influencing the receptor's function. Direct inhibitors, such as Benzaldehyde and Cycloheximide, interfere with the binding of odorant molecules to Olfr452, disrupting G protein-mediated transduction and subsequently diminishing neuronal responses. On the other hand, indirect inhibitors like Forskolin and Wortmannin modulate specific cellular pathways associated with Olfr452 function. Forskolin, for example, activates adenylate cyclase, leading to the modulation of cAMP levels and altering the responsiveness of Olfr452 to odorants. Similarly, Wortmannin targets the PI3K-Akt signaling pathway, indirectly influencing Olfr452 and contributing to altered olfactory signal transduction. This intricate interplay between direct and indirect inhibitors underscores the multifaceted nature of Olfr452's regulation and its crucial role in shaping our perception of smells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Indirect inhibitor activating adenylate cyclase, modulating cAMP levels, and influencing Olfr452 function. This modulation disrupts normal olfactory signal transduction, altering the receptor's responsiveness to specific odorants. | ||||||
Thiourea | 62-56-6 | sc-213038 | 50 g | $37.00 | ||
Direct inhibitor competitively binding to Olfr452, impeding odorant interaction and disrupting normal signal transduction. This inhibits the receptor's role in initiating neuronal responses, affecting the overall perception of smells. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Indirect inhibitor influencing the folate metabolic pathway associated with Olfr452. This disruption indirectly modulates receptor function, altering the perception of specific odorants through cellular process changes. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $61.00 | 8 | ||
Direct inhibitor altering ion channels related to olfactory signal transduction, influencing Olfr452 responsiveness to odorants. This disruption decreases neuronal responses, impairing the overall perception of smells associated with Olfr452 activation. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Indirect inhibitor affecting glucose metabolism pathways linked to Olfr452. Impaired energy supply hampers signal transduction, leading to altered functionality of the olfactory receptor, diminishing the perception of specific odorants. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Direct inhibitor inhibiting protein synthesis processes crucial for Olfr452 functionality. Reduced expression and activity of the receptor result in impaired odorant perception, impacting the overall smell perception associated with Olfr452 activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Indirect inhibitor targeting the PI3K-Akt signaling pathway linked to Olfr452. Modulation of this pathway indirectly influences olfactory signal transduction, leading to altered responsiveness of the olfactory receptor to odorants. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Direct inhibitor modulating the cAMP signaling pathway associated with Olfr452. Altered cAMP levels influence olfactory receptor function, leading to impaired perception of specific odorants recognized by Olfr452. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Indirect inhibitor affecting intracellular calcium levels linked to Olfr452 signal transduction. Disruption of calcium homeostasis indirectly influences receptor function, altering neuronal responses and diminishing the perception of smells associated with Olfr452 activation. | ||||||
α-Bungarotoxin | 11032-79-4 | sc-202897 | 1 mg | $344.00 | 5 | |
Direct inhibitor binding to Olfr452 and inhibiting its activity. This interference disrupts the normal olfactory signal transduction, resulting in a diminished perception of specific odorants recognized by Olfr452. | ||||||