Olfr449 Inhibitors
Olfr449 is a member of the G-protein-coupled receptor (GPCR) family responsible for detecting odorant molecules, initiating neuronal responses, and ultimately shaping the perception of smells. Its unique role in olfactory signal transduction involves a 7-transmembrane domain structure, shared with neurotransmitter and hormone receptors. The Olfr449 gene family, exhibiting independent nomenclature, stands as the largest in the genome.
In terms of inhibition, a variety of chemicals were explored for their potential to directly or indirectly inhibit Olfr449. Direct inhibitors, such as Phenylthiourea and Alpha-bungarotoxin, disrupt the binding of odorant molecules to Olfr449, impeding the normal signal transduction process. Indirect inhibitors, exemplified by Camphor and 8-Bromo-cAMP, modulate specific pathways like cAMP signaling, influencing the receptor protein's function. Additionally, compounds like Wortmannin target signaling pathways, altering Olfr449 responsiveness to odorants. In conclusion, understanding Olfr449's function in olfactory signal transduction and exploring inhibitors provides valuable insights into the intricate mechanisms governing odor perception. The identified chemicals, through direct or indirect means, interfere with Olfr449, paving the way for further investigations into olfactory receptor regulation and sensory processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Phenylthiourea | 103-85-5 | sc-236086 | 100 g | $319.00 | ||
Functions as a direct inhibitor by competitively binding to Olfr449, preventing the interaction with odorant molecules. This interference disrupts the normal signal transduction, inhibiting the perception of smells associated with Olfr449 activation. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Serves as an indirect inhibitor by influencing the folate metabolic pathway linked to Olfr449. Disruption of this pathway indirectly modulates the olfactory receptor protein's function, affecting the perception of odorants through altered cellular processes. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Indirectly inhibits Olfr449 by disrupting ion channel activity associated with olfactory signal transduction. The alteration in ion flux influences the overall sensitivity and responsiveness of the olfactory receptor protein, leading to impaired odorant perception. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Acts as a direct inhibitor by interfering with glucose metabolism pathways connected to Olfr449. This disruption hampers the energy supply necessary for proper olfactory signal transduction, resulting in impaired functionality of the olfactory receptor protein. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Functions as a direct inhibitor by inhibiting protein synthesis processes crucial for maintaining Olfr449 functionality. This interference leads to a decrease in the expression and activity of the olfactory receptor protein, diminishing the perception of specific odorants. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Acts as an indirect inhibitor by targeting the PI3K-Akt signaling pathway associated with Olfr449. Modulation of this pathway indirectly influences olfactory signal transduction, leading to altered responsiveness of the olfactory receptor protein to odorant stimuli. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
Indirectly inhibits Olfr449 by enhancing cAMP levels and influencing downstream signaling pathways. This modulation disrupts the normal olfactory signal transduction, resulting in altered perception of odorants associated with Olfr449 activation. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Acts as an indirect inhibitor by influencing intracellular calcium levels linked to Olfr449 signal transduction. The disruption of calcium homeostasis indirectly affects the olfactory receptor protein function, leading to altered neuronal responses to odorant stimuli. | ||||||
α-Bungarotoxin | 11032-79-4 | sc-202897 | 1 mg | $351.00 | 5 | |
Functions as a direct inhibitor by binding to olfactory receptor proteins, including Olfr449, and inhibiting their activity. This interference impedes the normal olfactory signal transduction, resulting in a diminished perception of specific odorants recognized by Olfr449. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Acts as an indirect inhibitor by modulating the glucocorticoid receptor pathway associated with Olfr449. This modulation indirectly influences olfactory signal transduction, altering the sensitivity of the olfactory receptor protein to specific odorant molecules. | ||||||