Olfr447 Inhibitors
Olfr447, a pivotal member of the olfactory receptor family, plays a central role in the initiation of neuronal responses that lead to the perception of smells. As a G-protein-coupled receptor (GPCR) with a characteristic 7-transmembrane domain structure, Olfr447 is essential for the recognition and G protein-mediated transduction of signals from odorant molecules. The olfactory receptor proteins, including Olfr447, emerge from single coding-exon genes, constituting the largest gene family in the genome.
Inhibition of Olfr447 involves a diverse set of chemicals targeting either the receptor directly or influencing associated signaling pathways. Direct inhibitors, such as Colchicine and Pertussis Toxin, disrupt microtubule dynamics and G protein function, respectively, impairing Olfr447 activation. Indirect inhibitors, like L-NMMA and SKF 96365, disrupt nitric oxide production and calcium dynamics, impacting downstream processes associated with olfactory signaling. The multifaceted approach to inhibition highlights the intricate nature of olfactory signal processing and offers valuable insights into the regulatory mechanisms governing olfactory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Direct inhibitor disrupting microtubule dynamics. Colchicine binds to tubulin, impairing the cytoskeleton structure of olfactory neurons. This direct inhibition limits the propagation of signals initiated by Olfr447 activation, impacting the receptor's ability to mediate the transduction of odorant signals and perceive smells. | ||||||
L-NG-Monomethylarginine, Acetate Salt (L-NMMA) | 53308-83-1 | sc-200739 sc-200739A sc-200739B sc-200739C | 25 mg 100 mg 1 g 100 g | $73.00 $224.00 $663.00 $39586.00 | 3 | |
Inhibitor of nitric oxide synthase (NOS). L-NMMA disrupts nitric oxide production, indirectly inhibiting Olfr447. The altered nitric oxide levels impact olfactory signaling by affecting neuronal response, thereby impairing the transduction of odorant signals and perception of smells. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
Intracellular calcium chelator. BAPTA-AM disrupts calcium-dependent processes involved in olfactory signal transduction by Olfr447. The altered calcium dynamics impair the receptor's ability to initiate a neuronal response to smells, limiting the transduction of odorant signals. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Direct inhibitor interfering with G protein function. Pertussis Toxin blocks Gαi signaling, impairing Olfr447 activation. This direct inhibition prevents the normal transduction of odorant signals, limiting the receptor's ability to initiate a proper neuronal response to smells. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
Inhibitor of store-operated calcium entry (SOCE). SKF 96365 disrupts the calcium influx crucial for olfactory signal transduction by Olfr447. The altered calcium dynamics impair the receptor's ability to initiate a neuronal response to smells, limiting the transduction of odorant signals. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Activator of L-type calcium channels. This indirect inhibitor influences calcium dynamics crucial for olfactory signal transduction by Olfr447. The altered calcium influx impairs the receptor's ability to initiate a neuronal response to smells, limiting the transduction of odorant signals. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $204.00 | 2 | |
Inhibitor of AMPA and kainate glutamate receptors. CNQX impacts glutamatergic signaling associated with Olfr447 activation. The altered glutamate signaling limits the receptor's ability to mediate the transduction of odorant signals and initiate a proper neuronal response to smells. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Inhibitor targeting the SERCA pump. Thapsigargin disrupts calcium dynamics crucial for olfactory signal transduction by Olfr447. The altered calcium dynamics impair the receptor's ability to initiate a neuronal response to smells, limiting the transduction of odorant signals. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $66.00 $280.00 $1300.00 | 11 | |
Antagonist of GABAA receptors. Picrotoxin disrupts GABAergic signaling associated with Olfr447 activation. The altered GABAergic signaling limits the receptor's ability to mediate the transduction of odorant signals and initiate a proper neuronal response to smells. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $153.00 $600.00 | 27 | |
Inhibitor of calmodulin. Calmidazolium disrupts calcium-calmodulin interactions crucial for olfactory signal transduction by Olfr447. The altered calcium-calmodulin dynamics impair the receptor's ability to initiate a neuronal response to smells, limiting the transduction of odorant signals. | ||||||