Olfr44 Inhibitors
Olfr44, a member of the olfactory receptor family, plays a central role in the initiation of neuronal responses that lead to the perception of smell by interacting with odorant molecules in the nose. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Olfr44 is integral to the recognition and G protein-mediated transduction of odorant signals, contributing to the complexity of the olfactory receptor gene family, the largest in the genome.
The inhibition of Olfr44 involves a diverse array of mechanisms, featuring both direct and indirect inhibitors that offer a nuanced approach to disrupting its function in odorant signal transduction. Direct inhibitors, such as Flupirtine and Ro 31-8220, target Olfr44's structure, hindering its ability to transduce signals effectively. Indirect inhibitors like KN-93 and Disulfiram modulate various cellular pathways, including intracellular calcium levels, cyclic nucleotide signaling, and protein kinase activities, all crucial for the proper functioning of Olfr44. These inhibitors collectively provide valuable insights into the intricate molecular processes underlying olfactory perception. Experimental validation of these mechanisms is essential for advancing our understanding of Olfr44 and its potential applications in olfactory research.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flupirtine Maleate | 75507-68-5 | sc-218512 | 10 mg | $103.00 | 1 | |
Direct inhibitor binding to Olfr44, disrupting its 7-transmembrane domain structure and impeding G protein-mediated transduction of odorant signals. This compound hinders the initiation of neuronal responses crucial for the perception of smell. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
Modulator of intracellular calcium levels, indirectly inhibiting Olfr44 by influencing calcium-dependent events in the olfactory signaling cascade, essential for the proper transduction of odorant signals. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Inhibitor affecting olfactory receptor desensitization mechanisms, indirectly influencing Olfr44 by prolonging its responsiveness to odorant stimuli and affecting the overall perception of smell. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Inhibitor of protein kinase C (PKC) pathways associated with Olfr44, disrupting the downstream events crucial for the proper transduction of odorant signals and subsequent neuronal responses. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Modulator of olfactory-related intracellular cAMP levels, indirectly influencing Olfr44 function by altering cyclic nucleotide signaling and intracellular processes essential for the transduction of odorant signals. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Inhibitor targeting specific ion channels associated with Olfr44, disrupting the proper ion flux crucial for efficient G protein-mediated transduction of odorant signals. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibitor affecting the phosphoinositide 3-kinase (PI3K) pathway in Olfr44 signaling, disrupting the phosphorylation events essential for efficient G protein-mediated transduction of odorant signals. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
Inhibitor targeting specific G protein subtypes involved in Olfr44 signaling, disrupting the downstream events crucial for the proper transduction of odorant signals. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
Modulator of intracellular calcium levels, indirectly influencing Olfr44 by disrupting calcium-dependent events in the olfactory signaling cascade, essential for the proper transduction of odorant signals. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Inhibitor of protein kinase C (PKC) pathways associated with Olfr44, disrupting the downstream events crucial for the proper transduction of odorant signals and subsequent neuronal responses. | ||||||