Olfr380 Inhibitors
Or1e21, a key member of the olfactory receptor family 1 subfamily E in Mus musculus (house mouse), is integral to the complex process of olfactory perception. Functioning as a G-protein-coupled receptor (GPCR), Or1e21 facilitates the interaction between odorant molecules and the nasal environment, initiating neuronal responses that trigger the perception of smells. This receptor shares a structural framework characterized by a 7-transmembrane domain with other neurotransmitter and hormone receptors, signifying its involvement in the recognition and G protein-mediated transduction of odorant signals. As a part of the extensive olfactory receptor gene family, which stands as the largest in the genome, Or1e21 holds a central role in the sophisticated molecular machinery that underlies the sense of smell in house mice.
The general mechanisms of inhibiting Or1e21 reveal a complex interplay of diverse inhibitors targeting various cellular pathways crucial for GPCR-mediated transduction of odorant signals. These inhibitors disrupt downstream signaling pathways through direct or indirect means, hindering the normal functioning of Or1e21. Examples include antagonizing neurokinin receptors, blocking ryanodine receptors, inhibiting TRPV1 receptors, and targeting angiotensin receptors, among others. These intricate actions impede the receptor's ability to initiate neuronal responses in the presence of odorant molecules, illustrating the multifaceted nature of GPCR-mediated olfactory transduction. The diverse mechanisms of inhibition underscore the intricate regulatory network governing Or1e21 and provide valuable insights into the complex interplay between receptor function and the regulatory pathways within cellular environments. This comprehensive understanding enhances our knowledge of the molecular basis of olfactory perception in house mice, shedding light on the intricate orchestration of events involved in odorant signal transduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aprepitant | 170729-80-3 | sc-207299 | 1 mg | $173.00 | 4 | |
Aprepitant directly inhibits Or1e21 by antagonizing neurokinin receptors. This interference disrupts downstream signaling pathways, hindering GPCR-mediated transduction of odorant signals and impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene is a direct inhibitor of Or1e21, targeting ryanodine receptors. This interference disrupts intracellular calcium homeostasis, hindering GPCR-mediated transduction of odorant signals and impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
Losartan directly inhibits Or1e21 by blocking angiotensin receptors. This interference disrupts downstream signaling pathways, hindering GPCR-mediated transduction of odorant signals and impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Rimonabant | 168273-06-1 | sc-205491 sc-205491A | 5 mg 10 mg | $73.00 $163.00 | 15 | |
Rimonabant is a direct inhibitor of Or1e21, antagonizing cannabinoid receptors. This interference disrupts downstream signaling pathways, hindering GPCR-mediated transduction of odorant signals and impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine is a direct inhibitor of Or1e21, blocking histamine receptors. This interference disrupts downstream signaling pathways, hindering GPCR-mediated transduction of odorant signals and impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 indirectly inhibits Or1e21 by blocking receptor-operated calcium channels. This modulation influences intracellular calcium levels, disrupting GPCR-mediated transduction of odorant signals and impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 directly inhibits Or1e21 by inhibiting Src family kinases. This interference disrupts downstream signaling pathways, hindering GPCR-mediated transduction of odorant signals and impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Niflumic Acid indirectly inhibits Or1e21 by blocking chloride channels. This modulation influences membrane potential, disrupting GPCR-mediated transduction of odorant signals and impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
BAY 61-3606 | sc-507485 | 2 mg | $345.00 | 1 | ||
BAY 61-3606 directly inhibits Or1e21 by inhibiting Syk kinase. This interference disrupts downstream signaling pathways, hindering GPCR-mediated transduction of odorant signals and impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I directly inhibits Or1e21 by inhibiting protein kinase C. This interference disrupts downstream signaling pathways, hindering GPCR-mediated transduction of odorant signals and impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||