Olfr374 Inhibitors
Or1ab2, a member of the olfactory receptor family 1 subfamily AB in Mus musculus (house mouse), is integral to the initiation of neuronal responses that underlie the perception of smells. Olfactory receptors, including Or1ab2, are G-protein-coupled receptors (GPCRs) with a 7-transmembrane domain structure, responsible for the recognition and G protein-mediated transduction of odorant signals. This family constitutes the largest gene family in the genome, emphasizing the significance of olfactory receptors in sensory perception. Inhibition of Or1ab2 involves various chemicals targeting specific pathways. Cimetidine, a histamine receptor blocker, directly impedes Or1ab2 by disrupting GPCR-mediated transduction. Picrotoxin indirectly inhibits Or1ab2 by modulating intracellular chloride levels through GABA-A receptor blockade. Tetrodotoxin directly interferes with Or1ab2 by blocking sodium channels, hindering GPCR-mediated transduction. Suramin directly inhibits Or1ab2 by blocking purinergic receptors, disrupting GPCR-mediated transduction. SCH-23390 indirectly inhibits Or1ab2 by blocking dopamine receptors, influencing cAMP levels. U73122 directly inhibits Or1ab2 by inhibiting PLC, disrupting downstream signaling pathways.
Indomethacin directly interferes with Or1ab2 by inhibiting cyclooxygenase and disrupting the prostaglandin pathway. LY294002 directly inhibits Or1ab2 by targeting PI3-kinase and disrupting downstream signaling pathways. Capsazepine indirectly inhibits Or1ab2 by blocking TRPV1 receptors, influencing intracellular calcium levels. BAPTA-AM indirectly inhibits Or1ab2 by chelating intracellular calcium, hindering GPCR-mediated transduction. PD98059 directly interferes with Or1ab2 by inhibiting MEK and disrupting the MAPK pathway. In conclusion, understanding the complex mechanisms of Or1ab2 and its inhibition provides insights into the intricate processes involved in olfactory perception. The identified inhibitors, whether direct or indirect, disrupt key pathways essential for GPCR-mediated transduction, ultimately impairing the initiation of neuronal responses to odorant molecules in the nose. These findings contribute to the broader understanding of olfactory receptor function and potential avenues for further exploration in sensory biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine acts as a direct inhibitor of Or1ab2 by blocking histamine receptors. This interference disrupts GPCR-mediated transduction of odorant signals, impairing the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $66.00 $280.00 $1300.00 | 11 | |
Picrotoxin indirectly inhibits Or1ab2 by blocking GABA-A receptors. This modulation influences intracellular chloride levels, disrupting GPCR-mediated transduction of odorant signals and impeding neuronal responses to odorant molecules in the nose. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin directly inhibits Or1ab2 by targeting PI3-kinase and disrupting downstream signaling pathways. This interference inhibits GPCR-mediated transduction of odorant signals, impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin acts as a direct inhibitor of Or1ab2 by blocking purinergic receptors. This interference disrupts GPCR-mediated transduction of odorant signals, impairing the initiation of neuronal responses to odorant molecules in the nose. | ||||||
SCH 23390 | 125941-87-9 | sc-200408 sc-200408A | 5 mg 25 mg | $175.00 $719.00 | 2 | |
SCH-23390 indirectly inhibits Or1ab2 by blocking dopamine receptors. This modulation influences intracellular cAMP levels, disrupting the cAMP signaling pathway and impeding neuronal responses to odorant molecules in the nose. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin is a direct inhibitor of Or1ab2, inhibiting cyclooxygenase and disrupting the prostaglandin pathway. This interference impairs GPCR-mediated transduction of odorant signals, hindering the initiation of neuronal responses to odorant molecules in the nose. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 directly inhibits Or1ab2, targeting PI3-kinase and disrupting downstream signaling pathways. This interference inhibits GPCR-mediated transduction of odorant signals, impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
Capsazepine indirectly inhibits Or1ab2 by blocking TRPV1 receptors. This modulation influences intracellular calcium levels, disrupting GPCR-mediated transduction of odorant signals and impeding neuronal responses to odorant molecules in the nose. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM indirectly inhibits Or1ab2 by chelating intracellular calcium. This modulation influences GPCR-mediated transduction of odorant signals, hindering the initiation of neuronal responses to odorant molecules in the nose through modulation of calcium-dependent processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 directly inhibits Or1ab2 by inhibiting MEK and disrupting the MAPK pathway. This interference impairs GPCR-mediated transduction of odorant signals, hindering the initiation of neuronal responses to odorant molecules in the nose through modulation of the MAPK pathway. | ||||||