Olfr372 Inhibitors
Or2z8, a member of the olfactory receptor family, plays a pivotal role in the olfactory system, specifically in Mus musculus. As an olfactory receptor, Or2z8 is involved in the detection of odorant molecules within the nose, initiating a neuronal response that leads to the perception of smell. Olfactory receptors, like Or2z8, are a part of the large family of G-protein-coupled receptors (GPCRs) characterized by a 7-transmembrane domain structure. This family of receptors is responsible for recognizing odorant signals and mediating G protein-dependent transduction, contributing to the intricate process of olfactory perception.
Inhibition of Or2z8 involves a comprehensive understanding of its signaling pathways and related cellular processes. The modulation of Or2z8 function can be achieved through the use of specific inhibitors that target crucial components of these pathways. The inhibition may occur directly through the interference with the olfactory receptor itself or indirectly by influencing associated signaling cascades. These inhibitors disrupt downstream events, leading to altered expression and function of Or2z8, ultimately impacting the perception of smell. The exploration of chemical inhibitors provides valuable insights into the molecular mechanisms underlying the regulation of Or2z8 and, by extension, the broader olfactory system. This knowledge contributes to a deeper understanding of the intricate interplay between signaling pathways and olfactory receptor function, paving the way for further investigations into the modulation of olfactory perception at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole, an antifungal agent, inhibits Or7c19 indirectly by modulating the cAMP signaling pathway. It disrupts membrane integrity, affecting downstream signal transduction and altering olfactory receptor protein function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, directly inhibits Or7c19 by disrupting the PI3K/AKT pathway. This interference leads to reduced downstream signaling, impacting the olfactory receptor function and impairing odorant signal transduction. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, indirectly inhibits Or7c19 by modulating the p38 MAPK pathway. Its action disrupts downstream events, affecting olfactory receptor protein expression and altering the perception of smell. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3K inhibitor, directly inhibits Or7c19 by disrupting the PI3K/AKT pathway. This interference leads to reduced downstream signaling, impacting the olfactory receptor function and impairing odorant signal transduction. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126, a MEK1/2 inhibitor, indirectly inhibits Or7c19 by modulating the MAPK/ERK pathway. Its action disrupts downstream events, affecting olfactory receptor protein expression and altering the perception of smell. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
LY2228820, an ERK inhibitor, indirectly inhibits Or7c19 by modulating the MAPK/ERK pathway. Its action disrupts downstream events, affecting olfactory receptor protein expression and altering the perception of smell. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, indirectly inhibits Or7c19 by modulating the JNK pathway. Its action disrupts downstream events, affecting olfactory receptor protein expression and altering the perception of smell. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059, a MEK1 inhibitor, indirectly inhibits Or7c19 by modulating the MAPK/ERK pathway. Its action disrupts downstream events, affecting olfactory receptor protein expression and altering the perception of smell. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542, a TGF-β receptor inhibitor, indirectly inhibits Or7c19 by modulating the TGF-β pathway. Its action disrupts downstream events, affecting olfactory receptor protein expression and altering the perception of smell. | ||||||
LY2090314 | 603288-22-8 | sc-507359 | 5 mg | $175.00 | ||
LY2090314, a GSK-3 inhibitor, indirectly inhibits Or7c19 by modulating the Wnt/β-catenin pathway. Its action disrupts downstream events, affecting olfactory receptor protein expression and altering the perception of smell. | ||||||