OIP5 Inhibitors
OIP5 inhibitors can be classified into a cohort of chemicals that have the capability to influence mitotic pathways and centromere or kinetochore functions. Given OIP5's central role in the kinetochore and its function during mitosis, any disruption to microtubule dynamics and kinetochore assembly can influence OIP5 activity. This context brings forth the significance of chemicals like Paclitaxel, Nocodazole, and Colchicine, which are known to modulate microtubule stability and polymerization. Furthermore, specific kinases, such as polo-like kinase (PLK1) and Aurora kinases, play pivotal roles in centromere dynamics and kinetochore attachments. Chemicals like BI 2536, ZM-447439, and Hesperadin, by targeting these kinases, provide an approach to influence OIP5 function indirectly.
Moreover, kinesin proteins are instrumental in spindle dynamics and kinetochore attachments. In this context, Monastrol and S-Trityl-L-cysteine, by inhibiting kinesin functions, can have an overarching impact on kinetochore activity and, by extension, OIP5. Additionally, the cell cycle's intricate regulation, where OIP5 plays its role during mitosis, is controlled by cyclin-dependent kinases. Purvalanol A, by targeting these kinases, showcases another dimension in modulating OIP5 function. Overall, these chemicals, through a web of pathways and processes, offer a multi-pronged approach to understanding and influencing OIP5 activity in mitosis
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Microtubule depolymerizing agent, can affect kinetochore-microtubule attachments and other mitotic spindle processes. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Binds to tubulin, inhibiting microtubule polymerization, which can influence kinetochore assembly and function. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Kinesin-5 inhibitor, can affect spindle bipolarity and centrosome separation, thus influencing kinetochore function. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
Inhibitor of polo-like kinase (PLK1), which can influence centromere and kinetochore function in mitosis. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Aurora kinase inhibitor, associated with centrosome function and kinetochore-microtubule attachments in mitosis. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Aurora B kinase inhibitor, can influence chromosome alignment and segregation by affecting kinetochore-microtubule ties. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
Inhibitor of Eg5 kinesin, which can affect spindle assembly and kinetochore attachments. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Inhibitor of cyclin-dependent kinases, can impact cell cycle progression and kinetochore assembly. | ||||||
Reversine | 656820-32-5 | sc-203236 | 5 mg | $217.00 | 13 | |
Aurora kinase inhibitor; kinetochore attachments and centromere functions can be affected during mitosis. | ||||||
Polo-like Kinase Inhibitor III | 660868-91-7 | sc-203202 | 500 µg | $107.00 | 1 | |
Inhibitor of PLK1, a kinase involved in multiple aspects of mitosis, including kinetochore and centromere function. | ||||||