ODR4 Inhibitors
Odorant response abnormal protein 4 (ODR4) Inhibitors are a diverse set of chemical compounds that attenuate the functional activity of ODR4 through various mechanisms impacting olfactory signaling pathways. Ibuprofen and capsaicin, by influencing prostaglandin synthesis and desensitizing sensory neurons respectively, lead to a subdued GPCR signaling which is critical for ODR4's role in olfactory perception. Quinine and Ruthenium Red, through their actions on potassium and calcium channels, alter the ionic balance and reduce the responsiveness of ODR4 in olfactory neurons. Similarly, lidocaine, bupivacaine, and tetrodotoxin, as sodium channel blockers, prevent the propagation of action potentials, consequently diminishing the activity of ODR4 by hindering signal transduction. Methyllycaconitine's antagonistic effect on nicotinic acetylcholine receptors and Omega-Conotoxin's selective inhibition of N-type calcium channels both disrupt neurotransmitter release, thereby indirectly suppressing ODR4 functionin olfactory signaling processes. Cadmium chloride and zinc sulfate, by blocking calcium channels and various ion channels respectively, impair neurotransmitter release and neuron excitability, which in turn indirectly diminish ODR4 function. Amiloride's blockade of ENaC channels alters the ionic environment critical for neuron excitability, further contributing to the attenuation of ODR4 activity in the olfactory system.
Collectively, these ODR4 inhibitors function by targeting specific components of the olfactory signaling cascade, from GPCR signaling modulation to ion channel activity regulation, leading to a comprehensive dampening of ODR4's role in olfactory perception. The inhibitors act by either changing the chemical environment surrounding ODR4, blocking the channels essential for initiating and propagating neuronal signals, or inhibiting receptors involved in neurotransmitter release. Each inhibitor's unique mechanism contributes to a cumulative decrease in ODR4's functional activity, underscoring the complexity of the olfactory transduction process and the potential points of intervention to modulate ODR4-mediated signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
Ibuprofen inhibits the cyclooxygenase pathway, resulting in decreased production of prostaglandins. These lipid compounds can modulate the activity of various proteins, including Odorant response abnormal protein 4 (ODR4), by affecting G-protein coupled receptor (GPCR) signaling, which is pivotal for ODR4 function in olfactory neurons. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates the transient receptor potential vanilloid 1 (TRPV1) channel, leading to calcium influx and subsequent desensitization of sensory neurons. This desensitization may diminish the sensitivity of ODR4, which is involved in olfactory signal transduction. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine is a known blocker of various ion channels, including potassium channels. By altering the ionic balance in olfactory neurons, it may decrease the sensitivity of ODR4, as proper ion channel function is necessary for the activation of olfactory signaling cascades. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine is a voltage-gated sodium channel blocker, which by inhibiting action potential propagation in neurons, would also diminish the activity of ODR4 by preventing signal transduction in olfactory sensory neurons. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red is an inhibitor of calcium channels, including TRPV channels. By inhibiting these channels, it can reduce the activation of downstream signaling pathways that are necessary for ODR4-mediated olfactory signal transduction. | ||||||
Methyllycaconitine citrate | 112825-05-5 | sc-253043 sc-253043A | 5 mg 25 mg | $117.00 $398.00 | 2 | |
Methyllycaconitine is an antagonist of nicotinic acetylcholine receptors, which can modulate the activity of neural pathways. Inhibition of these receptors could decrease neurotransmitter release and diminish the overall neuronal activity, thereby indirectly inhibiting ODR4 function. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium Chloride is a blocker of calcium channels, which play a role in the regulation of neurotransmitter release and neuron excitability. By inhibiting these channels, the chemical may indirectly lead to reduced ODR4 activity by impairing olfactory neuron signaling. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Sulfate can act as an inhibitor of various ion channels and receptors. By modulating these ion channels, it may influence neuronal excitability and thus indirectly affect the functional activity of ODR4 in olfactory signal transduction. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is a blocker of epithelial sodium channels (ENaC) and certain other ion channels. Since ENaCs are expressed in olfactory receptor neurons, amiloride's action could lead to a diminished response in ODR4 activity by altering the ionic environment and neuronal excitability. | ||||||