Molecular structure of Methyllycaconitine citrate, CAS Number: 112825-05-5
Methyllycaconitine citrate (CAS 112825-05-5)
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Alternate Names:
MLA
Application:
Methyllycaconitine citrate is a potent antagonist for α7-containing neuronal nicotinic receptors
CAS Number:
112825-05-5
Purity:
≥95%
Molecular Weight:
874.92
Molecular Formula:
C37H50N2O10•C6H8O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Methyllycaconitine citrate is a potent and selective antagonist of nicotinic acetylcholine receptors. It functions by binding to the receptor and blocking the action of acetylcholine, leading to the inhibition of ion channel opening. Methyllycaconitine citrate′s mechanism of action involves targeting the alpha7 subtype of nicotinic acetylcholine receptors. Its ability to selectively block these receptors may be useful in studying the involvement of nicotinic acetylcholine receptors in synaptic transmission, learning, memory, and other neurological functions.
Methyllycaconitine citrate (CAS 112825-05-5) References
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- Nicotinic modulation of Ca2+ oscillations in rat cortical neurons in vitro. | Wang, J., et al. 2016. Am J Physiol Cell Physiol. 310: C748-54. PMID: 26843531
- Alpha-7 Nicotinic Receptor-Targeted Cinobufagin Induces Antinociception and Inhibits NF-κB Signaling Pathway in DRG Neurons. | Xu, L., et al. 2019. ACS Chem Neurosci. 10: 497-506. PMID: 30247877
- Low-dose nicotine promotes autophagy of cardiomyocytes by upregulating HO-1 expression. | Xing, R., et al. 2020. Biochem Biophys Res Commun. 522: 1015-1021. PMID: 31813548
- Activation of α7nACh receptor protects against acute pancreatitis through enhancing TFEB-regulated autophagy. | Li, B., et al. 2020. Biochim Biophys Acta Mol Basis Dis. 1866: 165971. PMID: 32950676
- Nicotine Prevents Oxidative Stress-Induced Hippocampal Neuronal Injury Through α7-nAChR/Erk1/2 Signaling Pathway. | Dong, Y., et al. 2020. Front Mol Neurosci. 13: 557647. PMID: 33328880
- Vagus nerve stimulation ameliorates L-NAME-induced preeclampsia-like symptoms in rats through inhibition of the inflammatory response. | Zheng, L., et al. 2021. BMC Pregnancy Childbirth. 21: 177. PMID: 33663436
- Electroacupuncture Ameliorates Acute Pancreatitis: A Role for the Vagus Nerve-Mediated Cholinergic Anti-Inflammatory Pathway. | Zhang, L., et al. 2021. Front Mol Biosci. 8: 647647. PMID: 34055878
- Studies on the role of alpha 7 nicotinic acetylcholine receptors in K562 cell proliferation and signaling. | Önder Narin, G., et al. 2021. Mol Biol Rep. 48: 5045-5055. PMID: 34143396
- Varenicline Prevents LPS-Induced Inflammatory Response via Nicotinic Acetylcholine Receptors in RAW 264.7 Macrophages. | Baris, E., et al. 2021. Front Mol Biosci. 8: 721533. PMID: 34712695
- Dexmedetomidine suppresses serum syndecan-1 elevation and improves survival in a rat hemorrhagic shock model. | Kobayashi, A., et al. 2022. Exp Anim. 71: 281-287. PMID: 35110424
- Alpha7 Nicotinic Acetylcholine Receptor Antagonists Prevent Meningitic Escherichia coli-Induced Blood-Brain Barrier Disruptions by Targeting the CISH/JAK2/STAT5b Axis. | Gong, Z., et al. 2022. Biomedicines. 10: PMID: 36289622
Inhibitor of:
AChRα10, AChRα4, AChRα5, AChRα9, B830028B13Rik, CHRFAM7A, Complexin-4, neuroligin 3, ODR4, Olfr31, Olfr779, OR2T34, OR5K4, Synaptotagmin V, V1RA1, V1rg10, Vmn2r122, and Vmn2r79.Activator of:
C6orf134.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methyllycaconitine citrate, 5 mg | sc-253043 | 5 mg | $119.00 | |||
Methyllycaconitine citrate, 25 mg | sc-253043A | 25 mg | $406.00 |