Odf3L1 Activators
Odf3L1 Activators encompass a diverse array of chemical compounds that indirectly enhance the functional activity of Odf3L1 through modulation of various signaling pathways. Forskolin and 8-Bromo-cAMP are notable for their ability to elevate intracellular cAMP levels, thereby activating PKA which can phosphorylate proteins that associate with or alter Odf3L1, enhancing its role within the cytoskeleton. Sphingosine-1-phosphate and Thapsigargin operate through distinct mechanisms involving lipid signaling and calcium homeostasis, respectively, leading to cytoskeletal rearrangements and calcium-dependent signaling that may enhance Odf3L1's structural functions. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which in turn can phosphorylate proteins that affect Odf3L1, while Ionomycin raises intracellular calcium levels, thus potentially increasing the functional activity of Odf3L1 by tuning the calcium signaling machinery. Epigallocatechin gallate (EGCG) indirectly augments Odf3L1 by inhibiting kinases that would otherwise phosphorylate proteins that negatively regulate Odf3L1, suggesting a nuanced approach to enhancing Odf3L1 activity by reducing negative regulatory influences.
Complementing these mechanisms, LY294002 and U0126 modulate PI3K/AKT and MEK1/2 signaling, respectively, which may indirectly result in the upregulation of Odf3L1's activity by altering cytoskeletal dynamics or shifting signaling equilibriums. Genistein, through its tyrosine kinase inhibition, may decrease competitive phosphorylation events that could interfere with Odf3L1's stability and function, while A23187, by increasing intracellular calcium, can stimulate pathways that promote Odf3L1's association with the cytoskeleton. Staurosporine, despite its broad kinase inhibition profile, might preferentially allow for the enhanced activity of Odf3L1 by lifting the inhibition exerted by specific kinases on proteins that interact with Odf3L1. Collectively, these chemical activators, through targeted effects on cellular signaling, facilitate the enhancement of Odf3L1-mediated functions, emphasizing the intricate web of signaling that governs its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene that activates the enzyme adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP) within the cell. Elevated cAMP can enhance Odf3L1 activity by activating protein kinase A (PKA), which may phosphorylate substrates that interact with or modify Odf3L1, thus enhancing its function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and acts as a potent activator of protein kinase C (PKC). Activation of PKC can lead to phosphorylation of proteins that associate with Odf3L1, indirectly enhancing its functional activity within the cytoskeletal framework of the cell. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore which increases intracellular calcium levels, triggering calcium-dependent signaling pathways. Elevated calcium may activate proteins that modify Odf3L1, enhancing its structural role within the cytoskeleton. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibitor properties. By inhibiting specific kinases, EGCG might reduce the phosphorylation of proteins that compete with or negatively regulate Odf3L1, thereby indirectly enhancing Odf3L1 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid that activates sphingosine-1-phosphate receptors, initiating signaling cascades that can lead to actin cytoskeletal rearrangement. This rearrangement could potentially enhance the functional role of Odf3L1 in the organization of cytoskeletal structures. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K). Inhibition of PI3K can alter AKT signaling, which might result in changes in cytoskeletal dynamics that enhance the functionality of Odf3L1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, enzymes within the MAPK pathway. By inhibiting MEK1/2, U0126 may shift the signaling equilibrium, potentially enhancing signaling pathways that upregulate Odf3L1 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that functions as a tyrosine kinase inhibitor. By inhibiting these kinases, Genistein may decrease the phosphorylation of proteins that modulate the stability and function of Odf3L1, thus indirectly enhancing its activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. By mimicking cAMP and activating PKA, it can phosphorylate and activate proteins that may interact with Odf3L1, enhancing its functionality within the cell. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that specifically transports calcium across cellular membranes, increasing intracellular calcium concentration. This increase can activate signaling pathways that enhance the association of Odf3L1 with the cytoskeleton, improving its functional activity. | ||||||