Odf3 Activators
Odf3 engage in various mechanisms to enhance its activation by modulating intracellular levels of cyclic AMP (cAMP), a messenger molecule that plays a pivotal role in many biological processes including those related to the function of Odf3. Forskolin, by directly stimulating adenylyl cyclase, raises cAMP levels, thereby enhancing the activation of Odf3. Similarly, Isoproterenol and Terbutaline, both beta-adrenergic agonists, activate adenylyl cyclase via G protein-coupled receptor signaling, leading to increased cAMP and subsequent activation of Odf3. The same is true for Prostaglandin E1 (PGE1) and Epinephrine, which bind to their respective G protein-coupled receptors, and Dopamine that interacts with D1-like receptors, all contributing to elevated cAMP levels and thus facilitating the activation of Odf3.
Rolipram and Anagrelide inhibit phosphodiesterases, enzymes responsible for breaking down cAMP, which in turn sustains higher levels of cAMP within the cell, promoting Odf3 activation. IBMX, a nonspecific phosphodiesterase inhibitor, also prevents cAMP degradation, contributing to the activation process of Odf3. Cholera Toxin exerts a more prolonged effect by irreversibly activating the Gs alpha subunit, resulting in continuous adenylyl cyclase activation and, consequently, sustained increase in cAMP levels that can lead to Odf3 activation. Histamine, through its action on H2 receptors, and Salbutamol, another beta2-adrenergic agonist, also elevate cAMP concentrations, further supporting the activation of Odf3. In summary, all these chemicals, by increasing intracellular cAMP, either through stimulation of its production or inhibition of its degradation, support the process of Odf3 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing levels of cyclic AMP (cAMP) in cells. As Odf3 is involved in sperm tail formation, and cAMP signaling is crucial for sperm motility and function, the increased cAMP could enhance Odf3 activity related to sperm flagella structure and function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, also increases intracellular cAMP levels by activating adenylyl cyclase through G protein-coupled receptor signaling. This elevation in cAMP may enhance Odf3 activation, as Odf3 has roles in cellular structures that could be cAMP-responsive. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which breaks down cAMP. By inhibiting PDE4, rolipram increases cAMP levels in cells, potentially leading to activation of Odf3 due to the importance of cAMP in regulating cell motility and structure, relevant to Odf3's function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX, or 3-isobutyl-1-methylxanthine, is a nonspecific inhibitor of phosphodiesterases, enzymes that degrade cAMP. By preventing cAMP degradation, IBMX could indirectly activate Odf3's function in cells where cAMP-mediated signaling is involved in the regulation of structural proteins. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
Prostaglandin E1 (PGE1) binds to its G protein-coupled receptor, which can lead to increased cAMP production. Elevated cAMP may activate Odf3 by enhancing signaling pathways that regulate structural components of cells, such as the cytoskeleton to which Odf3 contributes. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine engages beta-adrenergic receptors, triggering a signaling cascade that results in increased cellular cAMP levels. This rise in cAMP could activate Odf3 by stimulating pathways that control cellular architecture and motility. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to its D1-like receptors that are coupled with Gs proteins, stimulating adenylyl cyclase and raising cAMP levels. This could lead to the activation of Odf3 as part of the response to cAMP-dependent signaling mechanisms. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, acting through H2 receptors, can increase intracellular cAMP levels. Through this mechanism, histamine could activate Odf3 by affecting signaling pathways that influence cellular structures and functions linked to Odf3's role. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline is a beta2-adrenergic receptor agonist that leads to elevated cAMP levels in cells. The resulting increase in cAMP may activate Odf3 by enhancing the function of pathways involved in the regulation of structural cellular components. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Anagrelide inhibits phosphodiesterase III, which increases cAMP levels. The increase in cAMP can activate Odf3 by influencing pathways that control cytoskeletal dynamics, which are relevant to Odf3's function within cells. | ||||||