OCT3 Activators
OCT3 Activators are substances that can modulate the activity of the OCT3 transporter. Many of these substances exert their effects indirectly, by influencing cellular processes or pathways that can regulate the expression or activity of OCT3. For example, substances such as forskolin, IBMX, and rolipram increase the levels of cyclic AMP, a second messenger that can regulate the expression and activity of various transporters, including OCT3.
Other OCT3 activators function by modulating the activity of protein kinases or phosphatases, enzymes that add or remove phosphate groups from proteins, respectively. These enzymes can regulate the activity of transporters like OCT3 by altering their phosphorylation state. Substances such as staurosporine, okadaic acid, calyculin A, genistein, PMA, H-89, LY294002, wortmannin, and U0126 fall into this category. By modulating the activity of these enzymes, these substances can indirectly influence the phosphorylation state and activity of OCT3.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cyclic AMP levels. Cyclic AMP can regulate numerous cellular processes, including the expression and activity of various transporters. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, leading to increased levels of cyclic AMP, potentially influencing the expression and activity of OCT3. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram selectively inhibits phosphodiesterase-4, which breaks down cyclic AMP, potentially influencing OCT3 activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. By modulating kinase activity, it may indirectly influence the phosphorylation state and activity of OCT3. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it may influence the phosphorylation state and activity of OCT3. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, potentially affecting the phosphorylation state and activity of OCT3. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a broad-spectrum tyrosine kinase inhibitor. By modulating kinase activity, it may indirectly influence the phosphorylation state and activity of OCT3. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C. It may influence the phosphorylation state and activity of OCT3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphatidylinositol 3-kinase. By inhibiting this kinase, it may influence the phosphorylation state and activity of OCT3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of phosphatidylinositol 3-kinase, potentially affecting the phosphorylation state and activity of OCT3. | ||||||