Date published: 2025-9-14

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OAT2 Inhibitors

Organic Anion Transporter 2 (OAT2) plays a significant role in the hepatic and renal uptake of various organic anions, including several drugs and endogenous substances. Direct inhibition of OAT2 is not well-established, but several compounds are known to interact with and potentially inhibit its transport function. Probenecid, a uricosuric agent, is a well-known inhibitor of several organic anion transporters and can compete with other substrates for transport via OAT2. Similarly, compounds such as Indomethacin, Ibuprofen, Ketoprofen, Diclofenac, and Piroxicam have been reported to inhibit OAT2, potentially affecting its substrate transport function.Diuretics like Furosemide also interact with OAT2, indicating the potential for altered transport of organic anions in the presence of these compounds. Agents such as Benzylpenicillin and Ciprofloxacin may also inhibit OAT2, affecting the disposition of endogenous compounds transported by OAT2.

Items 1 to 10 of 13 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Probenecid-d14

sc-219644
1 mg
$273.00
(0)

Probenecid-d14 acts as a selective inhibitor of the OAT2 transporter, showcasing unique molecular interactions that influence substrate affinity. Its isotopic labeling allows for precise tracking in metabolic studies, revealing insights into transport kinetics and pathway dynamics. The compound's structural features promote specific binding to the transporter, modulating its activity and potentially altering the overall organic anion transport mechanism within cellular environments.

Probenecid

57-66-9sc-202773
sc-202773A
sc-202773B
sc-202773C
1 g
5 g
25 g
100 g
$27.00
$38.00
$98.00
$272.00
28
(2)

Probenecid is known to inhibit various organic anion transporters, including OAT2, thus can indirectly affect OAT2 function by competing for transport.

Indomethacin

53-86-1sc-200503
sc-200503A
1 g
5 g
$28.00
$37.00
18
(1)

Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), has been shown to inhibit OAT2, potentially reducing its transport activity.

Furosemide

54-31-9sc-203961
50 mg
$40.00
(1)

Furosemide, a loop diuretic, can act as an inhibitor of OAT2, thereby affecting the transport of organic anions.

Ibuprofen

15687-27-1sc-200534
sc-200534A
1 g
5 g
$52.00
$86.00
6
(0)

Ibuprofen, another NSAID, can interact with and potentially inhibit OAT2, impacting its transport function.

Ketoprofen

22071-15-4sc-205359
sc-205359A
5 g
25 g
$93.00
$308.00
2
(0)

Ketoprofen, also an NSAID, has the potential to inhibit OAT2 and affect its anion transport activity.

Diclofenac acid

15307-86-5sc-357332
sc-357332A
5 g
25 g
$107.00
$292.00
5
(1)

Diclofenac may inhibit OAT2, thus affecting the transport of organic anions by this transporter.

Penicillin G sodium salt

69-57-8sc-257971
sc-257971A
sc-257971B
sc-257971C
sc-257971D
1 mg
10 mg
1 g
5 g
100 g
$25.00
$36.00
$46.00
$168.00
$260.00
1
(0)

Benzylpenicillin (Penicillin G) can interact with OAT2 and potentially inhibit its transport function.

Ciprofloxacin

85721-33-1sc-217900
1 g
$42.00
8
(1)

Ciprofloxacin, a fluoroquinolone antibiotic, has been reported to inhibit OAT2, thereby affecting its transporter activity.

Methotrexate

59-05-2sc-3507
sc-3507A
100 mg
500 mg
$92.00
$209.00
33
(5)

Methotrexate, an antimetabolite and antifolate drug, can inhibit OAT2, impacting the transport of organic anions.