Nup98 Activators
The chemical class known as Nup98 Activators comprises a diverse group of compounds that exert their influence on the nucleoporin Nup98 through various signaling pathways and cellular processes. Retinoic acid activates the retinoic acid receptor (RAR) signaling pathway, indirectly impacting Nup98 expression by influencing the transcriptional regulation of genes related to nucleocytoplasmic transport. Forskolin, a potent adenylate cyclase activator, elevates cAMP levels, modulating the PKA pathway and affecting cellular processes associated with nucleocytoplasmic transport, providing an indirect avenue for Nup98 modulation. Lithium chloride, through activation of the Wnt/β-catenin pathway, indirectly influences Nup98 by altering the canonical Wnt signaling cascade, impacting nucleocytoplasmic transport processes.
Epigallocatechin gallate (EGCG), a polyphenol, activates AMP-activated protein kinase (AMPK), indirectly affecting Nup98 by regulating cellular energy status and processes related to nucleocytoplasmic transport through downstream signaling events. These compounds collectively exemplify the intricate web of interactions that define the Nup98 Activators, demonstrating their ability to modulate nucleocytoplasmic transport processes through diverse biochemical and cellular pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, activates the retinoic acid receptor (RAR) signaling pathway. RAR can modulate Nup98 expression indirectly by influencing the transcriptional regulation of genes involved in cellular processes related to nucleocytoplasmic transport. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP levels influence the PKA pathway, which in turn can impact nucleocytoplasmic transport processes. This indirect modulation may affect Nup98 dynamics by altering the cellular environment. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates the Wnt/β-catenin signaling pathway. While Wnt activation is restricted, this chemical can indirectly influence Nup98 by modulating the canonical Wnt pathway, potentially affecting cellular processes associated with nucleocytoplasmic transport. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a polyphenol, can activate AMP-activated protein kinase (AMPK). Activation of AMPK may indirectly impact Nup98 by regulating cellular energy status and processes related to nucleocytoplasmic transport through downstream signaling cascades. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate various signaling pathways, potentially influencing Nup98 dynamics by modulating calcium-dependent processes associated with nucleocytoplasmic transport. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose inhibits glycolysis and activates the AMPK pathway. AMPK activation may indirectly affect Nup98 by modulating cellular energy sensing and influencing processes related to nucleocytoplasmic transport through downstream signaling events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) signaling. PKC activation can influence cellular processes, including nucleocytoplasmic transport. Although the exact mechanisms are not fully elucidated, the indirect modulation of Nup98 may occur through PKC-mediated signaling events. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase (HDAC) inhibitor, leading to histone hyperacetylation. HDAC inhibition can affect gene expression, potentially modulating Nup98 levels indirectly through epigenetic regulation and influencing processes related to nucleocytoplasmic transport. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin induces endoplasmic reticulum stress and activates the unfolded protein response (UPR). UPR activation may influence Nup98 indirectly by affecting cellular stress responses and processes related to nucleocytoplasmic transport through interconnected signaling pathways. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits DNA topoisomerase II and activates DNA damage responses. DNA damage signaling pathways can indirectly influence Nup98 by modulating cellular responses to stress, potentially affecting nucleocytoplasmic transport processes in the context of DNA repair. | ||||||