NumbL Inhibitors
Chemical inhibitors of NumbL can target various signaling pathways with which this protein is associated to achieve functional inhibition. LY294002 and Wortmannin are inhibitors of phosphoinositide 3-kinases (PI3Ks), which play a significant role in the PI3K/Akt signaling pathway. Given that NumbL interacts within this pathway, these inhibitors can lead to a reduction in Akt phosphorylation, a necessary step for NumbL to mediate its cellular effects. Similarly, Rapamycin and PP242 directly inhibit mTOR, a downstream component of the PI3K/Akt/mTOR pathway. Inhibition of mTOR results in decreased signaling potential, thereby limiting the functional contributions of NumbL in this pathway. PF-4708671, by selectively inhibiting p70 ribosomal S6 kinase 1 (S6K1), operates further downstream in the same PI3K/Akt pathway, leading to reduced phosphorylation of S6K1's targets and therefore diminishing NumbL's functional activity.
In addition to the PI3K/Akt/mTOR pathway, NumbL's function can be inhibited through disruption of the MAPK/ERK pathway. U0126, PD98059, and SL327 are selective inhibitors of MEK1/2, which act upstream of ERK. These inhibitors prevent ERK activation, thereby inhibiting downstream signaling that involves NumbL. SB203580 and BIX 02189 target other kinases within the MAPK pathway, namely p38 MAP kinase and MEK5, respectively. By disrupting these kinases' activities, they prevent the phosphorylation and activation of downstream effectors that would otherwise interact with NumbL. SP600125's inhibition of c-Jun N-terminal kinase (JNK) also serves to inhibit the MAPK pathway, affecting the cellular processes in which NumbL is involved. Lastly, AZD8055, a potent inhibitor of both mTORC1 and mTORC2 complexes, disrupts the PI3K/Akt/mTOR pathway at multiple levels, offering a broad inhibition of NumbL's role within this signaling cascade.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3Ks). NumbL is known to interact with PI3K signaling. Inhibition of PI3K can lead to a decrease in Akt phosphorylation, which is necessary for NumbL-mediated cell fate decisions. By inhibiting PI3K, LY294002 can reduce Akt activity, thereby inhibiting the downstream effects of NumbL. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK1/2, which are upstream of ERK in the MAPK/ERK pathway. NumbL is implicated in the MAPK/ERK signaling pathway. The inhibition of MEK1/2 prevents the activation of ERK, potentially reducing the phosphorylation of proteins that are part of the signaling cascade where NumbL is involved, resulting in functional inhibition of NumbL's role in this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. NumbL has been associated with the MAPK pathway. By inhibiting p38 MAP kinase, SB203580 can disrupt the MAPK signaling cascade, leading to decreased activity of downstream effectors that interact with NumbL, functionally inhibiting NumbL's role in this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). JNK is part of the MAPK signaling pathways which NumbL may interact with. By inhibiting JNK, SP600125 can disrupt the activity of downstream targets within this pathway, inhibiting the cellular processes in which NumbL is involved. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. As NumbL is known to interact with PI3K signaling, the inhibition of PI3K by Wortmannin would suppress Akt phosphorylation and thus inhibit the downstream signaling that involves NumbL. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 selectively inhibits MEK, which works upstream of ERK in the MAPK pathway. By inhibiting MEK, PD98059 can decrease the phosphorylation and activation of ERK, thereby inhibiting the downstream signaling events in which NumbL participates. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a key component in the PI3K/Akt/mTOR pathway. Since NumbL is involved in PI3K signaling, the inhibition of mTOR by Rapamycin leads to attenuated downstream signaling, thereby inhibiting the biological processes that NumbL influences within this pathway. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
PP242 is a selective inhibitor of mTOR kinase activity. By directly inhibiting mTOR, PP242 disrupts the PI3K/Akt/mTOR signaling axis, thereby functionally inhibiting the role of NumbL in this pathway by reducing the pathway's overall signaling potential. | ||||||
BIX 02189 | 1094614-85-3 | sc-364436 sc-364436A | 5 mg 10 mg | $224.00 $386.00 | 5 | |
BIX 02189 is a selective inhibitor of MEK5, a kinase implicated in the MAPK pathway. Through MEK5 inhibition, BIX 02189 suppresses the ERK5 pathway, potentially inhibiting the downstream effects on cellular processes where NumbL is functionally involved. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is an inhibitor of MEK1/2. By inhibiting MEK1/2, SL327 prevents the activation of ERK1/2, potentially inhibiting the downstream signaling in which NumbL is involved within the MAPK/ERK pathway. | ||||||