NUDT13 Activators
NUDT13 activators are chemical compounds that interact with the NUDT13 enzyme, a member of the Nudix hydrolase family. The Nudix family comprises a broad group of enzymes that have the capability to hydrolyze various nucleoside diphosphate derivatives. NUDT13, in particular, is an enzyme that has been identified to play a role in the metabolism of certain intracellular compounds, although the full extent of its biological functions remains an area of active research. Activators of NUDT13 are designed to enhance the enzyme's natural activity. Rather than inhibiting the enzyme, which is a more common approach in the modulation of enzymatic function, activators bind in a manner that increases the enzyme's catalytic efficiency or stability, potentially altering the concentration of specific biochemical substrates or products within the cell. The precise mechanism by which these chemicals activate NUDT13 can vary, often involving an allosteric site distinct from the enzyme's active site where substrate processing occurs.
The chemical structure of NUDT13 activators can be diverse, reflecting the complexity of modulating enzyme activity in a precise manner. These activators may mimic the structure of natural substrates, yet they are modified to enhance their interaction with the enzyme rather than being processed by it. Alternatively, they may bind to regions of the enzyme that induce a conformational change, which, in turn, enhances the enzyme's natural activity. The development of such activators often involves a detailed understanding of the enzyme's structure and dynamics, as it is necessary to identify potential allosteric sites or key amino acid residues that can be targeted to increase activity. This typically requires a combination of computational modeling and empirical biochemical assays to confirm the efficacy of the potential activators. By fine-tuning the activity of NUDT13, these activators contribute to the understanding of the enzyme's role within the cell and can help elucidate the complex pathways in which NUDT13 is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. Elevated cAMP levels can indirectly enhance NUDT13 activity by activating protein kinase A (PKA), which may phosphorylate and modulate proteins that interact with or regulate NUDT13. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways. By mimicking cAMP, it can activate PKA, which could enhance NUDT13 activity through similar mechanisms as Forskolin by modulating the cellular environment of NUDT13. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, enzymes responsible for breaking down cAMP. By preventing cAMP degradation, IBMX can indirectly increase NUDT13 activity through sustained PKA activation, potentially affecting proteins that govern NUDT13's function. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK). Upon activation, AMPK can enact various cellular changes, possibly inducing a metabolic state that indirectly promotes NUDT13 activity through alteration of nucleotide pools or associated signaling pathways. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin indirectly activates AMPK. Similar to AICAR, metformin can influence cellular energy balance and nucleotide availability, thereby potentially enhancing NUDT13's functional role in nucleotide metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to activate sirtuin 1 (SIRT1), which is involved in deacetylation of proteins. Through SIRT1 activation, resveratrol may indirectly influence the acetylation state of proteins interacting with NUDT13, thus affecting its activity. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is known to induce autophagy through inhibition of the acetyltransferase EP300. Enhanced autophagy can lead to the removal of potentially inhibitory or degradative cellular components that may otherwise negatively impact NUDT13 activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is a GSK-3 inhibitor, which can lead to the activation of Wnt signaling pathway, thereby potentially influencing the cellular context in which NUDT13 operates, leading to enhanced activity due to changes in cellular growth and metabolism. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN is a precursor of NAD+, and its supplementation can increase intracellular NAD+ levels, potentially modulating sirtuin activity. This modulation may indirectly affect NUDT13 activity via sirtuin-mediated protein interactions or metabolic changes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor which can lead to changes in chromatin state and gene expression patterns. While not directly activating NUDT13, it could create a more permissive cellular environment for its activity. | ||||||