NUDT12 Activators
NUDT12 activators function through a variety of biochemical mechanisms that indirectly influence the activity of this specific nudix hydrolase. Some activators work by modulating intracellular second messenger levels, such as cAMP and cGMP, which activate protein kinases like PKA and PKG. These kinases are responsible for phosphorylating numerous proteins within the cell, a post-translational modification that could lead to the enhancement of NUDT12's enzymatic activity or influence its interaction with other cellular proteins. Other activators impact cellular metabolism and energy balance. For instance, compounds that stimulate AMPK can lead to a cascade of phosphorylation events that may affect NUDT12. This could involve changes in the metabolic signaling pathways that indirectly increase the functional activity of NUDT12 by altering the availability of substrates or cofactors necessary for its hydrolase activity.
Additionally, some NUDT12 activators exert their effects by influencing gene expression and protein modification processes. Certain molecules can induce DNA damage responses or modulate chromatin structure, potentially leading to an upregulation of repair pathways that could involve NUDT12. Activation of proteins such as SIRT1 by small molecules could result in altered acetylation patterns of proteins that interact with or regulate NUDT12, thereby modifying its activity. Furthermore, changes in lipid metabolism induced by fatty acids can affect the lipid microenvironment of NUDT12, potentially influencing its activity due to the enzyme's association with lipid substrates or membrane components.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-specific inhibitor of phosphodiesterases, which leads to elevated cAMP and cGMP levels, indirectly activating PKA and PKG pathways that could enhance NUDT12 activity through phosphorylation processes. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cAMP analog that activates PKA. PKA can phosphorylate substrates that may interact with NUDT12, potentially leading to its increased activity. | ||||||
8-Bromo-cGMP | 51116-01-9 | sc-200316 sc-200316A | 10 mg 50 mg | $104.00 $354.00 | 7 | |
Analog of cGMP that activates PKG, which in turn could phosphorylate and activate proteins that modulate NUDT12 activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMP-activated protein kinase (AMPK), which can phosphorylate various downstream targets, potentially leading to increased activity of NUDT12 through altered metabolic signaling. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Activates AMPK, a master regulator of cellular energy homeostasis, which may indirectly increase NUDT12 activity by modulating cellular metabolism and phosphorylation status. | ||||||
Carmustine | 154-93-8 | sc-204671 sc-204671A sc-204671-CW | 25 mg 100 mg 25 mg | $107.00 $326.00 $131.00 | 1 | |
Alkylating agent that induces DNA damage responses, potentially leading to activation of repair pathways where NUDT12 might be functionally upregulated as part of the response to DNA damage. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates SIRT1, which deacetylates proteins and could influence NUDT12 activity by changing the acetylation status of proteins that interact with or regulate NUDT12. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
A non-specific phosphodiesterase inhibitor, leading to increased cAMP levels, which can activate PKA and potentially result in increased NUDT12 activity through phosphorylation. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
A fatty acid that alters lipid metabolism and signaling, which may affect NUDT12 activity by modifying the lipid environment where NUDT12 exerts its function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates various signaling pathways, including the inhibition of NF-κB, which can alter the cellular environment and potentially lead to increased NUDT12 activity through stress response pathways. | ||||||