Nuak1 Activators
NUAK1 Activators encompass a diverse array of chemical compounds that indirectly facilitate the activation of NUAK1 through various mechanisms. These compounds do not directly interact with NUAK1; instead, they influence signaling cascades that lead to NUAK1's activation. The primary mode of indirect activation originates from the modulation of AMPK activity. For example, metformin and AICAR are known to activate AMPK, subsequently leading to the phosphorylation of downstream kinases, including NUAK1. Activation of AMPK, often in response to cellular energy stress, promotes the phosphorylation of NUAK1, enhancing its kinase activity associated with cellular processes such as glucose starvation response and regulation of myosin-light-chain-phosphatase activity.
Resveratrol and other compounds like berberine also operate by influencing the AMPK pathway, albeit through different molecular interactions. Other chemicals in this class may affect cyclic AMP levels, modulate gene expression, or alter cellular redox states, leading to changes in the signaling environment that can indirectly result in the activation of NUAK1. While the precise biochemical events may vary, the collective impact of these compounds on cellular signaling networks ultimately converges on the functional activation of NUAK1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin, a biguanide antihyperglycemic agent, activates AMP-activated protein kinase (AMPK), a known upstream kinase of NUAK1. By activating AMPK, metformin indirectly promotes the phosphorylation and activation of NUAK1, as AMPK can phosphorylate NUAK1 on specific threonine residues, leading to its activation. This process is particularly relevant under conditions of cellular energy stress, such as glucose starvation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an adenosine analog that activates AMPK. Upon administration, AICAR is converted to an intermediate that mimics AMP, leading to AMPK activation. Activated AMPK can subsequently phosphorylate and activate NUAK1, thereby influencing processes such as cellular senescence and myosin-light-chain-phosphatase activity regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenolic compound found in red wine that has been shown to activate SIRT1, a NAD+-dependent deacetylase. SIRT1 activation can lead to the deacetylation and activation of LKB1, a kinase that phosphorylates and activates AMPK. Through this pathway, resveratrol can indirectly lead to the activation of NUAK1 via the AMPK pathway. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylate, the active component of aspirin, has been shown to activate AMPK. By activating AMPK, salicylate can indirectly stimulate NUAK1 activity due to the role of AMPK as an upstream kinase that phosphorylates NUAK1, leading to its activation. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine is an isoquinoline alkaloid that activates AMPK. It promotes the activation of NUAK1 indirectly through AMPK-mediated phosphorylation. Berberine’s action on AMPK and subsequent activation of NUAK1 is relevant in the context of regulating cellular energy homeostasis. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $29.00 $164.00 $255.00 | 2 | |
Trehalose is a disaccharide that has been reported to activate AMPK. Through AMPK activation, trehalose can indirectly enhance the phosphorylation and activation of NUAK1, contributing to the cellular response to stress conditions, including glucose starvation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that has been found to activate AMPK. By stimulating AMPK, quercetin can lead to the subsequent phosphorylation and activation of NUAK1, influencing processes like cellular senescence and response to DNA damage. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is a methylxanthine that has been reported to activate AMPK. Though primarily known for its central nervous system stimulant effects, caffeine can indirectly stimulate NUAK1 via AMPK activation, impacting cellular energy balance and stress responses. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN is a precursor of NAD+ that can increase SIRT1 activity. Activated SIRT1 can lead to the deacetylation and activation of LKB1, which in turn activates AMPK. Through this pathway, NMN can indirectly facilitate the activation of NUAK1 by AMPK-mediated phosphorylation. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium salicylate is a sodium salt form of salicylate that, similar to its acid counterpart, activates AMPK. Consequently, it can promote the phosphorylation and activation of NUAK1 indirectly through the AMPK pathway. | ||||||