NSUN1 Activators
NSUN1 Activators encompass a series of chemical compounds that are integral to the catalytic methylation function of the enzyme. ATP is fundamental for NSUN1, providing the necessary energy for its methylation reactions, with the enzyme's activity being directly proportional to ATP availability. S-Adenosylmethionine serves as the methyl group donor for NSUN1, making it another direct contributor to the protein's activity; an upsurge in SAM levels can significantly enhance the methylation of RNA by NSUN1. Additionally, NAD+ supports the energy metabolism for NSUN1's functions, while Cobalt(II) chloride can induce an indirect enhancement of NSUN1 activity by promoting RNA methylation under hypoxic conditions, a cellular state that often influences methylation patterns.
Further supporting the activity of NSUN1 are compounds that contribute to the synthesis of SAM or stabilize enzyme activity. Vitamin B12 and folic acid are crucial for one-carbon metabolism, which is pivotal for SAM production, hence indirectly boosting NSUN1's methyltransferase function. Zinc sulfate may enhance NSUN1 by improving enzyme stability, while magnesium chloride promotes ATP binding, a necessary step forNSUN1's enzymatic activity. L-Methionine serves as a substrate in the methionine cycle, leading to the generation of SAM, and an increase in its cellular concentration can bolster NSUN1's methylation capacity. Similarly, betaine, as a methyl donor in the methionine cycle, and choline chloride, through its contribution to betaine synthesis, can enhance NSUN1 activity by ensuring a steady supply of SAM.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP is a substrate for NSUN1, as NSUN1 is a methyltransferase that utilizes ATP in its catalytic methylation reactions. The presence of ATP is crucial for the methylation of RNA by NSUN1, thereby directly enhancing its functional activity. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
SAM serves as the methyl donor for NSUN1. Thus, the availability of SAM is directly linked to the methyltransferase activity of NSUN1, and increased levels of SAM could enhance NSUN1's function in RNA modification. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is involved in redox reactions within the cell. While not a direct activator, increased concentrations of NAD+ can support the energy metabolism required for NSUN1-mediated reactions. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Cobalt(II) chloride can induce hypoxic conditions which have been shown to enhance the methylation activity of certain methyltransferases. This may indirectly increase the activity of NSUN1 as cellular adaptation to hypoxia can include alterations in RNA methylation patterns. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
As a precursor to the tetrahydrofolate cofactor, which is involved in one-carbon metabolism, folic acid is essential in the synthesis of SAM. By ensuring adequate SAM production, folic acid indirectly supports the methyltransferase activity of NSUN1. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $39.00 $55.00 $204.00 $877.00 $3414.00 $9180.00 | 2 | |
Vitamin B12 is another cofactor involved in one-carbon metabolism and SAM synthesis. Adequate levels of vitamin B12 support the methyltransferase activity of NSUN1 by promoting SAM availability. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc acts as a cofactor for many enzymes, including some RNA methyltransferases. While it is not a direct activator, zinc supplementation could potentially enhance NSUN1 activity by stabilizing the enzyme structure. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium ions are important co-factors for ATP-binding enzymes. As NSUN1 requires ATP for its methyltransferase activity, magnesium chloride can indirectly enhance its activity by facilitating ATP binding and hydrolysis. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
L-Methionine is the precursor to SAM in the methionine cycle. By increasing the cellular levels of L-methionine, SAM production is supported, indirectly enhancing NSUN1 activity by ensuring methyl group availability. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $30.00 $40.00 $55.00 $160.00 $330.00 $580.00 | 2 | |
Betaine participates in the methionine cycle as a methyl donor, contributing to SAM synthesis. An increase in betaine levels can, therefore, indirectly enhance the activity of NSUN1 by increasing SAM availability. | ||||||