NSE2 Inhibitors
NSE2 inhibitors belong to a class of chemical compounds that specifically target and modulate the activity of the NSE2 protein, also known as NSMCE2 (Nuclear Structural Maintenance of Chromosomes 2), a critical component of the SUMOylation pathway in cells. SUMOylation is a post-translational modification process where Small Ubiquitin-like Modifier (SUMO) proteins are covalently attached to target proteins, thereby regulating their stability, localization, and function. NSE2, as part of the SUMO E3 ligase complex, plays a pivotal role in facilitating the transfer of SUMO moieties to target proteins.
NSE2 inhibitors typically work by interfering with the enzymatic activity of NSE2, stopping the transfer of SUMO proteins to their intended substrates. These compounds are designed to bind to specific binding sites on NSE2, disrupting its catalytic function and, as a result, perturbing the SUMOylation process. This inhibition can have profound effects on cellular processes, as SUMOylation is involved in the regulation of diverse biological functions, including DNA repair, transcriptional regulation, protein stability, and cellular response to stress. The development and study of NSE2 inhibitors have provided valuable insights into the role of SUMOylation in various cellular pathways, making them important tools for basic research in cell biology and molecular biology.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $138.00 | 4 | |
Mirin is a small molecule that inhibits the MRE11-RAD50-NBS1 (MRN) complex, which is involved in DNA damage response and may indirectly affect NSE2 function related to DNA repair. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is an ATR kinase inhibitor which could impact NSE2 by altering the DNA damage response pathway where ATR is a key player. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
NU7441 is a DNA-dependent protein kinase (DNA-PK) inhibitor which could indirectly inhibit NSE2 activity by disrupting DNA repair pathways. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
KU-55933 is an ATM kinase inhibitor, potentially affecting NSE2-related functions by modulating the cellular response to DNA damage. | ||||||
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $243.00 $1015.00 | 1 | |
KU-60019 is another ATM inhibitor that can influence NSE2 function through the DNA damage response pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3 kinase inhibitor that may affect NSE2 by disrupting signaling pathways that involve PI3K related to DNA damage repair. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, another PI3K inhibitor, could have an indirect effect on NSE2 activity through the PI3K-AKT signaling pathway. | ||||||
ETP-46464 | 1345675-02-6 | sc-497432 | 10 mg | $550.00 | ||
ETP-46464 is an inhibitor of the MRN complex, potentially influencing NSE2 by altering the cellular response to DNA damage. | ||||||
PF 477736 | 952021-60-2 | sc-362781 sc-362781A | 5 mg 25 mg | $113.00 $423.00 | ||
PF-477736 is a checkpoint kinase 1 (CHK1) inhibitor which may indirectly affect NSE2 by modulating the DNA damage response checkpoints. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 is another CHK1 inhibitor that can have an indirect effect on NSE2 through the DNA damage response pathway. | ||||||