NSE2 Activators
NSE2 activators delineate a distinct group of chemicals that, though not directly stimulating NSE2, can influence conditions under which the significance of NSE2 becomes paramount. Their modus operandi typically revolves around inducing DNA damage or causing replication stress, scenarios wherein the genome's integrity is threatened and the cellular machinery, including NSE2, is marshaled to rectify these perturbations.
Foremost among these are agents like Hydroxyurea and Camptothecin, known for their propensity to hinder DNA replication and topoisomerase function, respectively. The resultant replication stress and DNA damage create a milieu where the SMC5-SMC6 complex's role, of which NSE2 is a part, gains prominence. Similarly, Cisplatin, Mitomycin C, and MMS are notorious for their ability to wreak havoc on the DNA's structure either by crosslinking or alkylating DNA bases. These alterations compel the cellular repair systems into action, a feat where NSE2's contribution is indispensable. Then there are compounds like Doxorubicin and 5-Fluorouracil, which insidiously integrate into the cellular DNA and RNA, respectively, leading to a cascade of events that can involve NSE2.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Inhibits DNA replication, causing replication stress which can lead to an increase in NSE2 activity as a compensatory response. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits DNA topoisomerase I leading to DNA damage, which can elevate the activity of NSE2. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Causes DNA crosslinking, leading to DNA damage and potentially invoking NSE2 activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Inhibits DNA topoisomerase II, leading to DNA damage, potentially increasing NSE2 function. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Crosslinks DNA, inducing DNA damage and potentially heightening NSE2 activity. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
Alkylating agent that damages DNA, which can elevate NSE2's role in damage repair. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Causes DNA breaks, potentially escalating the activity or expression of NSE2. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Intercalates with DNA causing damage and can potentially enhance NSE2 activity. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Incorporated into RNA and DNA, causing damage which can amplify NSE2 function. | ||||||