NRIF2 Inhibitors
NRIF2 inhibitors are chemical compounds that specifically target and modulate the activity of NRIF2, which stands for nuclear receptor-interacting factor 2. NRIF2 is a protein that interacts with nuclear receptors, which are transcription factors that regulate the expression of genes involved in various cellular processes, including metabolism, homeostasis, and cellular differentiation. NRIF2 plays a role in modulating the transcriptional activity of nuclear receptors by acting as a co-repressor or co-activator, depending on the cellular context and the type of nuclear receptor involved. The primary function of NRIF2 is to influence gene expression by modifying the chromatin structure or by recruiting other co-regulatory proteins that can either activate or repress transcription. Inhibitors of NRIF2 function by disrupting its interaction with nuclear receptors, altering its ability to affect gene expression and providing a means to study the biological functions of NRIF2 in different cellular pathways.
These inhibitors can be diverse in their chemical structures and modes of action, targeting various aspects of NRIF2's function. Some compounds may directly interfere with the binding interface between NRIF2 and its partner nuclear receptors, while others may affect the ability of NRIF2 to recruit other co-regulatory proteins or modify chromatin. By inhibiting NRIF2, researchers can elucidate the specific roles of NRIF2 in gene regulation and its downstream effects on cellular functions. The use of NRIF2 inhibitors provides a valuable tool to explore the mechanisms by which nuclear receptors regulate a variety of cellular processes and how NRIF2 contributes to the fine-tuning of these regulatory pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a potent and selective inhibitor of c-Raf kinase, which indirectly affects NRIF2 activity by modulating downstream signaling pathways linked to the neurotrophin receptor p75. This compound can lead to altered NRIF2-mediated transcriptional regulation by influencing signaling cascades. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which is a part of the MAPK/ERK pathway. This pathway is known to interact with neurotrophin signaling, thereby indirectly influencing NRIF2 activity. PD98059 reduces ERK phosphorylation, which can modulate NRIF2 function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK (c-Jun N-terminal kinase), which is involved in various cellular processes including those affected by neurotrophin signaling. By inhibiting JNK, SP600125 can indirectly impact NRIF2 activity, especially in pathways related to cell cycle regulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor, effective in blocking the MAPK/ERK pathway. Its action leads to decreased ERK activation, thereby potentially influencing NRIF2's role in neurotrophin signaling and cell cycle regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of PI3K, a key kinase in the PI3K/AKT pathway which intersects with neurotrophin signaling. By inhibiting PI3K, LY294002 can indirectly modulate NRIF2 activity, particularly in processes related to cellular survival and proliferation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. Its inhibition of PI3K can affect downstream signaling pathways that influence NRIF2 activity, particularly in the context of neurotrophin-mediated responses. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. The p38 MAP kinase pathway is involved in stress responses and can intersect with neurotrophin signaling, potentially affecting NRIF2 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and proliferation. This inhibition can indirectly impact NRIF2 activity by affecting general cellular regulatory mechanisms that might intersect with NRIF2 functions. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a kinase inhibitor with targets including RAF, VEGFR, and PDGFR. Its broad kinase inhibition can indirectly affect NRIF2 activity through modulation of various signaling pathways, including those involved in neurotrophin signaling. | ||||||
Erlotinib Hydrochloride | 183319-69-9 | sc-202154 sc-202154A | 10 mg 25 mg | $74.00 $119.00 | 33 | |
Erlotinib is an EGFR inhibitor. By inhibiting EGFR, erlotinib can impact cellular processes and signaling pathways that may indirectly modulate NRIF2 function, especially in relation to cell cycle regulation. | ||||||