NRIF2 Activators
Chemicals classified as NRIF2 Activators exert their influence indirectly, as they are not direct agonists that bind to and activate NRIF2 itself. Instead, these compounds modulate various signaling pathways and affect cellular processes that can impact the activation state of NRIF2. The primary mechanisms through which these activators function include the alteration of second messenger levels such as cAMP and calcium, the modulation of kinase and phosphatase activity, and the regulation of gene expression through epigenetic modifications.
The modulation of kinase activity, for instance, can lead to the phosphorylation of transcription factors or other proteins that may be involved in the regulation of NRIF2, thereby affecting its expression levels or its ability to interact with binding partners. Similarly, by altering the epigenetic landscape of the cell, compounds like HDAC inhibitors or DNA methyltransferase inhibitors can lead to the upregulation of genes that encode proteins which interact with NRIF2, thus indirectly modulating its activity. These activators work within the complex network of intracellular signaling, making the precise outcomes on NRIF2 function context-dependent and reliant on the cellular environment and the presence of specific cofactors and interacting proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate various calcium-dependent signaling molecules such as calmodulin-dependent kinase (CaMK), which could modify the activity of certain transcription factors or other proteins interacting with NRIF2, thereby influencing its cellular functions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and acts as a potent activator of protein kinase C (PKC). Activation of PKC has been implicated in a wide array of cellular processes, including the modulation of transcription factor activity, which may affect the expression or function of NRIF2. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, acts as a ligand for retinoic acid receptors (RARs) which are transcription factors. The binding of retinoic acid to RARs can induce changes in gene expression that could influence the activity or expression of NRIF2 by altering the cellular context within which NRIF2 operates. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Br-cAMP is a cell-permeable analog of cAMP that can activate PKA. By activating PKA, this compound may mimic the effects of forskolin, leading to alterations in cellular signaling pathways that modulate the activity or expression of NRIF2. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Similar to A23187, the increase in calcium can activate signaling pathways involving CaMK, which might affect NRIF2 function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), leading to increased phosphorylation levels of various proteins within the cell. This alteration in the phosphorylation state can impact multiple signaling pathways, potentially affecting NRIF2 activity indirectly. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is known to inhibit glycogen synthase kinase 3 (GSK-3). Inhibition of GSK-3 can lead to stabilization and activation of many proteins and transcription factors, which might then affect NRIF2 either by direct interaction or by altering the cellular environment in which NRIF2 functions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an inhibitor of histone deacetylases (HDACs). By altering the acetylation status of histones, TSA influences the chromatin structure and thereby regulates gene expression. This could lead to changes in the expression levels of genes that encode proteins interacting with or regulating NRIF2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analog that inhibits DNA methyltransferases, leading to hypomethylation of DNA. The hypomethylated state of DNA can result in the activation of genes that might be silenced otherwise. This can potentially influence the expression of NRIF2 or its regulatory proteins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea with multiple cellular targets. One of the mechanisms includes modulation of kinase pathways, which can impact the phosphorylation status of various proteins and potentially influence NRIF2 activity indirectly. | ||||||