NPAP1 Inhibitors
NPAP1 inhibitors are a category of chemical compounds designed to interfere with the function of a particular protein known as Nuclear Pore-Associated Protein 1 (NPAP1). The nuclear pore complex (NPC) is a critical gateway controlling the exchange of molecules between the nucleus and the cytoplasm, and NPAP1 plays a significant role in the regulation of this traffic. NPAP1 inhibitors target the specific interactions or the biochemical pathways associated with this protein, aiming to modulate its activity. The inhibition of NPAP1 can have a profound impact on the cellular level, affecting various nuclear transport processes. These substances are carefully structured to interact with NPAP1, often by binding to its active site or allosteric sites, thereby altering its natural function. The design of these inhibitors relies on a deep understanding of the protein's structure-function relationship, and the development of these compounds involves a meticulous process of chemical synthesis and molecular engineering.
The scope of NPAP1 inhibitors extends to the intricacies of molecular biology and biochemistry, where the regulation of nucleocytoplasmic transport is a subject of extensive study. The study of NPAP1 and its inhibitors involves sophisticated techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and various forms of mass spectrometry, alongside computational methods for molecular modeling. These techniques contribute to a deeper understanding of the binding kinetics, thermodynamics, and structural dynamics that define the interaction between NPAP1 and its inhibitors. By elucidating the precise mechanisms by which these inhibitors exert their effects, researchers can fine-tune the properties of these compounds, optimizing their selectivity and potency.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a tyrosine kinase inhibitor that specifically inhibits BCR-ABL, c-Kit, and PDGFR. As NPAP1 is associated with nuclear pore complex functions and may interact with cellular signaling molecules, inhibition of tyrosine kinases can alter the signaling cascade that potentially regulates NPAP1's role in nucleocytoplasmic transport. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K). Given that PI3K signaling is involved in a multitude of cellular processes, including trafficking and cytoskeletal rearrangements, LY294002 may indirectly affect NPAP1's functional role in the nuclear pore complex by disrupting upstream signaling events. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Wiskostatin is an inhibitor of the N-WASP which is essential for actin polymerization. Since NPAP1 is involved in nuclear transport, the inhibition of actin polymerization could impact the cellular architecture and indirectly affect the localization and function of NPAP1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor leading to an increase in cytosolic calcium levels. Elevated cytosolic calcium can modify various signaling pathways, potentially influencing the cellular environment and indirectly affecting NPAP1's functioning within the nuclear pore complex. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. As NPAP1 may be influenced by changes in cellular signaling, the inhibition of the MAPK pathway could indirectly affect NPAP1's activity related to nucleocytoplasmic transport. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and as a result, can disrupt normal microtubule dynamics. Since microtubule dynamics are essential for various cellular processes including intracellular transport, paclitaxel may indirectly influence NPAP1's role in the nuclear pore complex by altering the transport mechanisms. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $56.00 $75.00 | 2 | |
Ivermectin is a positive allosteric modulator of the α7-nicotinic acetylcholine receptor and is known to disrupt various intracellular transport pathways. By influencing these pathways, ivermectin could indirectly impact the function of NPAP1 in nuclear transport. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A is an inhibitor of ADP-ribosylation factor (ARF), which is involved in the regulation of vesicle trafficking. Disruption of vesicle trafficking can indirectly influence NPAP1's role in nucleocytoplasmic trafficking by altering the cellular transport environment. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine A is an immunosuppressant that binds to cyclophilins and inhibits calcineurin. By inhibiting calcineurin, cyclosporine A can affect various signaling pathways that may indirectly alter the function of NPAP1 within the nuclear pore complex. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can disrupt protein synthesis and cell growth pathways. Given that NPAP1 is involved in nuclear transport, the inhibition of mTOR signaling could indirectly affect NPAP1's role by altering cellular growth and transport processes. | ||||||