Molecular structure of Ivermectin, CAS Number: 70288-86-7
Ivermectin (CAS 70288-86-7)
See product citations (2)
Application:
Ivermectin is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor
CAS Number:
70288-86-7
Purity:
≥98%
Molecular Weight:
875.1
Molecular Formula:
C48H74O14 (B1a form)
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ivermectin is a positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Ivermectin acts as an antihelmintic. Ivermectin also modulates glutamate- and GABA-activated chloride channel and potentiates glycine-gated currents at low concentrations (30 nM).
Ivermectin (CAS 70288-86-7) References
- Behavioral effects of ivermectin in a freshwater oligochaete, Lumbriculus variegatus. | Ding, J., et al. 2001. Environ Toxicol Chem. 20: 1584-90. PMID: 11434302
- ESI+ MS/MS confirmation of canine ivermectin toxicity. | Lehner, AF., et al. 2009. J Mass Spectrom. 44: 111-9. PMID: 18853478
- A review of the pharmacological interactions of ivermectin in several animal species. | González-Canga, A., et al. 2009. Curr Drug Metab. 10: 359-68. PMID: 19519344
- Environmental fate of the anthelmintic ivermectin in an aerobic sediment/water system. | Prasse, C., et al. 2009. Chemosphere. 77: 1321-5. PMID: 19846198
- New ventures in the genotoxic and cytotoxic effects of macrocyclic lactones, abamectin and ivermectin. | Molinari, G., et al. 2010. Cytogenet Genome Res. 128: 37-45. PMID: 20389039
- Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination. | Chaccour, CJ., et al. 2013. Malar J. 12: 153. PMID: 23647969
- Subcutaneously injected ivermectin-loaded mixed micelles: formulation, pharmacokinetics and local irritation study. | Dong, J., et al. 2016. Drug Deliv. 23: 2220-2227. PMID: 25188004
- Low doses of ivermectin cause sensory and locomotor disorders in dung beetles. | Verdú, JR., et al. 2015. Sci Rep. 5: 13912. PMID: 26350768
- Ivermectin and malaria control. | Ōmura, S. and Crump, A. 2017. Malar J. 16: 172. PMID: 28438169
- Ivermectin dissipation and movement from feces to soil under field conditions. | Iglesias, LE., et al. 2018. J Environ Sci Health B. 53: 42-48. PMID: 28949805
- Ivermectin: a mini-review. | Johnson-Arbor, K. 2022. Clin Toxicol (Phila). 60: 571-575. PMID: 35225114
- Ivermectin and curcumin cause plasma membrane rigidity in Leishmania amazonensis due to oxidative stress. | Alonso, L., et al. 2022. Biochim Biophys Acta Biomembr. 1864: 183977. PMID: 35654148
- Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization. | Bondarenko, V., et al. 2023. ACS Chem Neurosci. 14: 1156-1165. PMID: 36821490
Inhibitor of:
4921537P18Rik, 4930434E21Rik, ABC-me, AChRα7, Alphavirus, ANKRD23, AZ2, BCRF1, Bestrophin (BEST), Bestrophin-2, Bestrophin-3, Bunyavirus, CAT56, CDV, CLC-4, CLCN5 (CLC-5), CLIC5, CPSF6, DDX17, Dengue Virus, ELYS, Esp3, FAM12, GABAA θ, GABAA 3, GABAA Rβ2, GABAA Rθ, GABAC Rρ3, Gle1, GlyR α2, GlyR α4, Gm14139, Gm14306, GTF2IRD2, HLA-DR, hnRNP Q, HSV-2 gB, IFITM5, Importin-12, Importin-8, karyopherin α1, karyopherin α2, karyopherin α5, karyopherin α6, karyopherin α7, karyopherin β2, karyopherin β3, KLHL10, LOC100041465, LOC399939, LOC497190, LOC728478, LRFN5, LRRC37A2, LRRC59, Measles H, Measles virus, mrnp41, NIPA, NLP, NPAP1, NTF2, Nup210L, OATP2A1, OATP8, Olfr345, Olfr853, Olfr854, Olr490, OR9A4, oskar, PAI-RBP1, PATE-E, POLR3E, Positive cofactor 4, PQLC2, PRPF39, PWP1, Rabies Virus, RACK1, Ran BP-6, reticulocalbin-2, RGD1309106, RGD1309170, ROD1, Seh1, SEL-12, SFRS14, Snurportin-1, SRp40, St. Louis encephalitis, ST18, SUDD, SUMO-1, SUSP4, SYCE2, TAPBPL, TCEAL2, THADA, THOC3, U2 snRNP A, V1RC19, Vmn2r100, Vmn2r123, VZV Major Capsid Protein, ZNF593, ZNF768, and ZNHIT2.Activator of:
ABCC11, AI747448, ASIC-β, ASIC2, CARD 12, CBP80, CLIC1, CLIC6, Coronavirus nucleocapsid, FMNL2, GABAA Rρ3, GlyR α1 (GLRA1), GlyR α3, GlyR β, gp210, Gtlf3b, HIV-1 Rev, hnRNP A3, Importin-7, Intelectin-2, ISOC2, karyopherin α7, KSHV ORF 45, La Crosse Virus G1, LRRC8A, LRRC8D, MEL-28, NLF1, Nup107, Nup153, Nup160, Nup37, Nup88, Nup93, NupL2, ODR-10, OR6V1, P2X2, P2X7, POM121L, PSE1, Ran BP-3, Ran BP-4, Rubella Virus capsid protein, Sec31A, and U2AF26.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ivermectin, 100 mg | sc-203609 | 100 mg | $57.00 | |||
Ivermectin, 1 g | sc-203609A | 1 g | $77.00 |