NOXRED1 Inhibitors
NOXRED1 inhibitors encompass a range of compounds that, while diverse in their primary targets, converge on the modulation of the redox state within cells, a key factor in NOXRED1 functioning. The mechanism of action of these inhibitors typically involves the reduction of reactive oxygen species (ROS) production, which NOXRED1 may utilize in its oxidoreductase processes. For example, certain compounds are known to directly target NADPH oxidase, an enzyme complex responsible for ROS generation, thus attenuating the oxidative stress that NOXRED1 is implicated in mitigating. This inhibition of NADPH oxidase can arise from either the suppression of its assembly or the blockade of its activity, leading to an environment that is less conducive to NOXRED1's optimal function. Additional compounds achieve similar outcomes by inhibiting flavoproteins or enzymes like xanthine oxidase, which are involved in the upstream processes of ROS production, thereby indirectly impacting the activity of NOXRED1.
The indirect approach to inhibiting NOXRED1 extends to molecules that mimic endogenous antioxidant enzymes or inhibit the synthesis of molecules that are crucial for the proper functioning of NADPH oxidase. For instance, one class of inhibitors includes molecules that act similarly to glutathione peroxidase, reducing the levels of hydrogen peroxide and other peroxides that could alter NOXRED1's activity. Other inhibitors target the mevalonate pathway, indirectly attenuating NADPH oxidase activity by affecting the availability of critical components necessary for its function. Through these varied but interconnected mechanisms, the cellular redox balance is shifted, rendering the environment less favorable for NOXRED1 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Apocynin | 498-02-2 | sc-203321 sc-203321A sc-203321B sc-203321C | 1 g 10 g 100 g 500 g | $26.00 $67.00 $114.00 $353.00 | 74 | |
An inhibitor of NADPH oxidase, which decreases the production of reactive oxygen species. The suppression of reactive oxygen species formation indirectly reduces the oxidative stress-related activity of NOXRED1. | ||||||
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $148.00 $133.00 $311.00 $397.00 $925.00 $1801.00 | 24 | |
Acts as an inhibitor of flavoproteins and can block NADPH oxidase activity, leading to decreased generation of superoxide anions which NOXRED1 might use for its oxidoreductase activity. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
An inhibitor of xanthine oxidase, reducing the production of uric acid and reactive oxygen species, thus potentially diminishing the oxidative environment NOXRED1 requires for its activity. | ||||||
2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | sc-501137 | 25 mg | $380.00 | |||
A dual inhibitor of NOX1 and NOX4, leading to a reduction in reactive oxygen species production and subsequently impacting the redox state which NOXRED1 is involved in balancing. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $50.00 $120.00 $420.00 $834.00 $1836.00 $4896.00 | 33 | |
An irreversible serine protease inhibitor that can also inhibit the assembly of NADPH oxidase components, potentially decreasing the production of reactive oxygen species and influencing NOXRED1’s oxidoreductase function. | ||||||
2-Acetylphenothiazine | 6631-94-3 | sc-223384 sc-223384A | 25 g 100 g | $74.00 $222.00 | ||
Selectively inhibits NOX1, leading to a reduction in reactive oxygen species and altering the redox environment that may affect NOXRED1 activity. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $32.00 $133.00 $449.00 | 5 | |
A glutathione peroxidase mimic and an indirect inhibitor of NADPH oxidase, leading to reduced reactive oxygen species and influencing the redox-dependent activity of NOXRED1. | ||||||
Plumbagin | 481-42-5 | sc-253283 sc-253283A | 100 mg 250 mg | $51.00 $61.00 | 6 | |
Inhibits NADPH oxidase-mediated generation of reactive oxygen species, which could affect the oxidoreductase activity of NOXRED1 by changing the redox state. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Inhibits HMG-CoA reductase, which can result in a reduction of NADPH oxidase activity and lower levels of reactive oxygen species, indirectly influencing NOXRED1 function. | ||||||
Glabridin | 59870-68-7 | sc-397145 sc-397145A | 5 mg 25 mg | $130.00 $520.00 | ||
An isoflavone that inhibits reactive oxygen species formation by suppressing the activity of NADPH oxidase, potentially modulating the redox state that NOXRED1 relies on for its activity. | ||||||