NOC3L Activators
NOC3L Activators are a select group of chemical compounds that indirectly enhance the functional activity of NOC3L through various epigenetic and cellular pathways. For instance, Nicotinamide adenine dinucleotide (NAD+) and Resveratrol enhance NOC3L function by facilitating sirtuin-mediated deacetylation of nuclear proteins, which is essential for proper chromatin dynamics, a process in which NOC3L is critically involved. Similarly, Trichostatin A and Sodium butyrate, as histone deacetylase inhibitors, indirectly promote NOC3L activity by increasing histone acetylation levels and thuscreating a more open chromatin state that NOC3L requires for nucleosome assembly. DNA methyltransferase inhibitor 5-Azacytidine also plays a role by inducing DNA demethylation, potentially affecting gene expression patterns that may favor NOC3L's role in chromatin remodeling.
Furthermore, compounds like Vitamin D3 and Retinoic acid indirectly support NOC3L activity through their respective receptor-mediated pathways that lead to chromatin remodeling, a prerequisite for effective nucleosome assembly orchestrated by NOC3L. Epigallocatechin gallate and Methylcobalamin influence the epigenetic landscape by respectively affecting gene expression and DNA methylation, thereby creating favorable conditions for NOC3L's function in chromatin organization. Additionally, the universal methyl donor S-Adenosylmethionine and Vorinostat, another HDAC inhibitor, can modulate the chromatin structure, potentially assisting NOC3L in its role within nucleosome assembly. Betulinic acid's ability to activate the p53 pathway, which is intricately involved in chromatin remodeling, further provides a conducive environment for NOC3L to enhance its chromatin-related functions. Collectively, these NOC3L Activators work through diverse but interconnected pathways that lead to the indirect enhancement of NOC3L's role in maintaining the dynamic structure of chromatin, crucial for the integrity of genomic functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
As a coenzyme in redox reactions, NAD+ can influence the activity of sirtuins, a class of deacetylase enzymes. NOC3L's function in the cell cycle and chromatin assembly could be enhanced by sirtuin-mediated deacetylation of histones and other nuclear proteins, thus promoting NOC3L's role in facilitating proper chromatin dynamics. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural compound that activates sirtuins, particularly SIRT1. By activating SIRT1, resveratrol can promote deacetylation processes that may enhance NOC3L function, which is implicated in nucleosome assembly and chromatin organization. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor (HDACi) that can increase the acetylation levels of histones. While TSA is generally known to relax chromatin structure, the subsequent heightened accessibility to DNA may indirectly enhance NOC3L function in chromatin assembly and modification. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can lead to DNA demethylation, potentially resulting in altered gene expression patterns. This may indirectly promote NOC3L's role in chromatin remodeling and nucleosome assembly by affecting the methylation status of chromatin. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
As a regulator of gene expression through the vitamin D receptor (VDR), Vitamin D3 can influence chromatin accessibility and remodeling. This could indirectly enhance NOC3L function by promoting a chromatin environment that is conducive to nucleosome assembly. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, through its interaction with retinoic acid receptors (RARs), can lead to chromatin remodeling. This may enhance NOC3L activity indirectly by creating a more open chromatin state that facilitates nucleosome assembly. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol found in green tea, EGCG has been shown to influence gene expression and DNA methylation. These epigenetic modifications can indirectly enhance the activity of NOC3L by altering the chromatin landscape, potentially facilitating chromatin assembly. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
As a universal methyl donor, SAM is involved in methylating DNA and histones, affecting chromatin structure and gene expression. This may indirectly enhance NOC3L function by creating a chromatin environment that is favorable for nucleosome assembly and dynamics. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor (HDACi), leading to increased acetylation of histones and a more open chromatin state. Indirectly, this could enhance NOC3L activity by facilitating its role in chromatin assembly and nucleosome organization. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another HDAC inhibitor, vorinostat, can increase histone acetylation, potentially impacting chromatin structure and gene expression. It may enhance NOC3L's function by promoting chromatin remodeling and nucleosome assembly. | ||||||