NO145 Inhibitors
Chemical inhibitors of NO145 act by disrupting the dynamics of the cellular cytoskeleton, which is essential for its function in meiotic processes. Phalloidin and Jasplakinolide target actin filaments, a key component of the cytoskeleton. Phalloidin binds to F-actin, stabilizing the filaments and thereby preventing their depolymerization. This stabilization can inhibit NO145 by disrupting the delicate balance of actin filament turnover required for its localization and function. Jasplakinolide also affects actin dynamics but does so by promoting polymerization and filament stability, which similarly can alter the actin dynamics necessary for NO145's role. In contrast, Latrunculin A, Cytochalasin D, Swinholide A, and Chondramide disrupt actin filaments through different mechanisms. Latrunculin A sequesters actin monomers, while Cytochalasin D caps the growing ends of filaments, both preventing the addition of new monomers. Swinholide A severs actin filaments and Chondramide binds to actin, inhibiting its polymerization, all of which can inhibit NO145 by altering the actin framework it relies on.
The inhibitors that target microtubules, another cytoskeletal element, also affect NO145's function. Colchicine, Nocodazole, and Vinblastine disrupt microtubule polymerization, while Paclitaxel and Epothilone B stabilize microtubules beyond their normal dynamics. Colchicine binds to tubulin, preventing microtubule assembly, and Nocodazole blocks polymerization, altering the dynamics and possibly the chromosome movements NO145 is associated with. Vinblastine binds to tubulin to prevent microtubule assembly, potentially affecting NO145's role in chromosome pairing. Conversely, Paclitaxel and Epothilone B prevent microtubule disassembly, which can also inhibit NO145 by preventing the normal dynamics of microtubules required for its function. Lastly, Griseofulvin disrupts microtubule function by binding to tubulin, which can inhibit NO145 by impairing the microtubule-dependent processes critical for the assembly or function of the synaptonemal complex during meiosis. Each of these chemicals, by affecting either actin or microtubule structures, can inhibit the normal function of NO145 in meiotic chromosome organization.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin binds to F-actin, stabilizing it and preventing its depolymerization, which can inhibit NO145 by disrupting the actin cytoskeleton dynamics the protein relies on for its localization and function within the cell, as NO145 is known to be associated with synaptonemal complex formation which is intimately connected to cytoskeletal structures. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts microfilament organization by sequestering actin monomers, which can inhibit NO145 by hindering proper actin cytoskeleton formation, thus potentially impairing NO145's role in synaptonemal complex assembly or function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, blocking polymerization and elongation. This can inhibit NO145 by impairing actin filament dynamics, which could be crucial for NO145's function in synapsis during meiosis. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide promotes actin polymerization and stabilizes filaments, which can inhibit NO145 by perturbing the dynamics of actin necessary for NO145's role in the synaptonemal complex and chromosome pairing during meiosis. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules. This can inhibit NO145 by disrupting the microtubule network, potentially affecting the positioning and movement of chromosomes that NO145 is involved with during meiosis. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which can inhibit NO145 by altering the microtubule dynamics that might be required for NO145's function in chromosome pairing and synaptonemal complex formation during meiosis. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds tubulin, preventing microtubule assembly, which can inhibit NO145 by disrupting microtubule formation that could be necessary for the proper functioning of NO145 in meiotic chromosomal processes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, preventing their disassembly, which can inhibit NO145 by altering microtubule dynamics and potentially affecting NO145's role in synaptonemal complex structure and function during meiosis. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A severs actin filaments and prevents their reannealing, which can inhibit NO145 by disrupting the actin cytoskeleton, possibly impeding NO145's function in the assembly or stability of the synaptonemal complex. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B stabilizes microtubules in a manner similar to paclitaxel, which can inhibit NO145 by preventing the normal microtubule dynamics that NO145 may utilize for its function in meiotic chromosome organization and synaptonemal complex formation. | ||||||