Nkx-2.4 Inhibitors
Nkx-2.4 Inhibitors encompass a broad range of chemical compounds, most of which target transcription factors in general or impact associated cellular pathways, thereby affecting the activity or expression of Nkx-2.4. Triptolide, for instance, can decrease transcription factors from binding to DNA, thereby blocking their function. Mithramycin A acts in a slightly different manner, selectively binding to GC-rich DNA sequences and thereby limiting the access of transcription factors.
The versatile JQ1 influences transcription regulation by inhibiting BET bromodomains, while ICG-001, a Wnt signaling inhibitor, affects a wide variety of transcription factors, given that the Wnt pathway is a nexus for various cellular processes. Cyclopamine's mode of action targets the Hedgehog signaling pathway, which, when inhibited, can affect downstream transcription factors and their activity.
Curcumin and Plumbagin represent another facet of this category. They are known to affect multiple pathways, with Curcumin being recognized for its inhibitory effect on the NF-kB transcription factor, and Plumbagin affecting both NF-kB and Stat3 transcription factor pathways. Chetomin, on the other hand, operates by disrupting the activity of p300/CBP-mediated transcription, which plays a role in several transcriptional pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Inhibits transcription factors by preventing their binding to DNA. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
BET bromodomain inhibitor, influencing transcription regulation. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $127.00 $192.00 $269.00 $502.00 $717.00 $1380.00 $2050.00 | 114 | |
Inhibits Stat3 transcription factor activation. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Binds to GC-rich DNA sequences, obstructing transcription factor binding. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Hedgehog pathway inhibitor, affecting downstream transcription factors. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Influences numerous pathways and can inhibit NF-kB transcription factor. | ||||||
Guggulsterone | 95975-55-6 | sc-203990 sc-203990A | 10 mg 50 mg | $145.00 $615.00 | 1 | |
FXR transcription factor antagonist. | ||||||
Plumbagin | 481-42-5 | sc-253283 sc-253283A | 100 mg 250 mg | $51.00 $61.00 | 6 | |
Inhibits NF-kB and Stat3 transcription factor pathways. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $182.00 $661.00 | 10 | |
Disrupts p300/CBP-mediated transcription. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Identified in silico to potentially bind and inhibit certain transcription factors. | ||||||