Nek6 Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
VEGFR2 Kinase Inhibitor III | 204005-46-9 | sc-202851 | 5 mg | $165.00 | 7 | |
SU9516 is a cyclin-dependent kinase inhibitor, which by affecting CDK2, can indirectly modulate NIMA-related kinase activity. Since NIMA-related kinase is involved in centrosome separation, which is tightly coordinated with the cell cycle, inhibition of CDK2 leads to cell cycle arrest, thereby affecting NIMA-related kinase′s role in mitosis. | ||||||
Purvalanol B | 212844-54-7 | sc-361300 sc-361300A | 10 mg 50 mg | $199.00 $846.00 | ||
Purvalanol A, a selective CDK inhibitor, particularly targeting CDK1, CDK2, and CDK5, can indirectly lead to the inhibition of NIMA-related kinase by disrupting the cell cycle progression and consequently mitotic processes where NIMA-related kinase is key. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $247.00 $888.00 | 1 | |
Targeting multiple CDKs, dinaciclib can impair cell cycle progression, influencing the activation of NIMA-related kinase, as its kinase activity is cell cycle-dependent, peaking in the G2/M phase. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is a potent and selective inhibitor of CDKs 2, 7 and 9. It affects transcription and cell cycle regulation, which can impact the regulation and function of NIMA-related kinase indirectly. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $62.00 $87.00 | 4 | |
Tozasertib is an Aurora kinase inhibitor. Since Aurora A kinase can phosphorylate NIMA-related kinase, its inhibition can reduce NIMA-related kinase activity indirectly by preventing its phosphorylation and activation. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib, an inhibitor of Aurora A kinase, can affect NIMA-related kinase indirectly by altering the phosphorylation state of proteins that are involved in centrosome duplication and separation, processes regulated by NIMA-related kinase. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
As a selective inhibitor of the kinesin Eg5, S-trityl-L-cysteine disrupts mitotic spindle formation. Since NIMA-related kinase regulates centrosomal cohesion, disrupting spindle dynamics can indirectly affect NIMA-related kinase's functional role. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor, with activity against both Aurora A and B. Inhibition of these kinases can disturb the phosphorylation state of proteins associated with NIMA-related kinase function. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Hesperadin inhibits Aurora B kinase, which is involved in chromosome alignment and segregation, processes that are also regulated by NIMA-related kinase, suggesting an indirect inhibition. | ||||||
AZ 3146 | 1124329-14-1 | sc-361114 sc-361114A | 10 mg 50 mg | $218.00 $905.00 | 7 | |
AZ3146 is a selective inhibitor of the mitotic checkpoint kinase Mps1, which is essential for the spindle assembly checkpoint, a process where NIMA-related kinase also has a role. | ||||||