VEGFR2 Kinase Inhibitor III (CAS 204005-46-9)
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VEGFR2 Kinase Inhibitor III is a cell-permeable ATP-competitive inhibitor of Flk-1 (VEGFR2/KDR, kinase insert domain receptor), which is the major growth factor for vascular endothelial cells. This receptor is a type III tyrosine kinase receptor that functions as the main mediator of VEGF-induced endothelial proliferation, survival, and migration. Studies suggest that VEGFR2 Kinase Inhibitor III also inhibits a variety of other receptors such as Met, Flt-3/Flk-2 (FLT-3 receptor tyrosine kinases), Ret, c-Kit, PDGFR, c-Abl and Arg (ABL), and ALK. In addition, VEGFR2 kinase inhibitor III regulates the signaling pathways used by oncogenic RET-transfected cells by regulating the extracellular signal regulated kinase (ERK) and JNK pathways.
VEGFR2 Kinase Inhibitor III (CAS 204005-46-9) References
- Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy. | Vajkoczy, P., et al. 1999. Neoplasia. 1: 31-41. PMID: 10935468
- Inhibition of RET tyrosine kinase by SU5416. | Mologni, L., et al. 2006. J Mol Endocrinol. 37: 199-212. PMID: 17032739
- Mechanism of inhibition of tumor angiogenesis by beta-hydroxyisovalerylshikonin. | Komi, Y., et al. 2009. Cancer Sci. 100: 269-77. PMID: 19200258
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VEGFR2 Kinase Inhibitor III, 5 mg | sc-202851 | 5 mg | $162.00 |