NIK Activators

Common NIK Activators include, but are not limited to Curcumin CAS 458-37-7, Resveratrol CAS 501-36-0, D,L-Sulforaphane CAS 4478-93-7, Quercetin CAS 117-39-5 and Andrographolide CAS 5508-58-7.

NIK Activators is a chemical class associated with the regulation of NF-κB-inducing kinase (NIK). NIK is a serine/threonine protein kinase that plays a pivotal role in the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway. The NF-κB pathway is a crucial cellular signaling cascade involved in the regulation of various biological processes, including immune responses, inflammation, cell survival, and development. NIK, as a key component of this pathway, functions by phosphorylating and activating specific downstream targets, ultimately leading to the activation of NF-κB transcription factors. These transcription factors, once activated, translocate to the nucleus and regulate the expression of genes involved in immune and inflammatory responses.

NIK activators are compounds or factors are typically substances that influence the activity or expression of NIK. By modulating NIK activity, these activators can impact the activation of NF-κB and, consequently, the expression of genes controlled by this pathway. Understanding the regulation of NIK and identifying compounds that can activate or inhibit its function is essential for deciphering the complexities of NF-κB signaling. Moreover, NIK activators are valuable tools in research aimed at unraveling the roles of the NF-κB pathway in various biological processes and cellular functions. They provide researchers with the means to explore the molecular mechanisms that govern this pathway.