NIF-1 Activators
NIF-1, which stands for Nucleolar complex protein 1 homolog, is a protein encoded by the gene NIF1 in humans. It is a multifunctional protein implicated in several cellular processes, particularly in chromatin remodeling and transcriptional regulation. NIF-1 is known to interact with the nucleosome remodeling deacetylase (NuRD) complex, a multiprotein assembly that is critical for altering chromatin structure to regulate gene expression.
NIF-1 has been shown to function as a transcriptional repressor, and its interaction with the NuRD complex suggests a role in histone deacetylation, an important epigenetic modification that typically leads to a more condensed chromatin state and transcriptional repression. The NuRD complex is involved in various cellular processes including development, differentiation, and DNA damage repair, which indicates that NIF-1 might also play a part in these vital activities.In addition to its role in chromatin remodeling, NIF-1 has been implicated in RNA processing and ribosome biogenesis, which are essential for protein synthesis and cell growth. This protein localizes predominantly to the nucleolus, the cell's hub for ribosomal RNA synthesis and ribosome assembly, suggesting that NIF-1 may contribute to the regulation of nucleolar functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Involved in gene expression regulation and cellular differentiation, potentially impacting NIF-1 regulated pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Influences gene expression and cellular proliferation, potentially affecting NIF-1 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Affects transcription factors and gene expression, possibly influencing NIF-1. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Regulates gene expression and cell growth, potentially impacting NIF-1 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Influences various signaling pathways and transcription factors, potentially impacting NIF-1. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Modulates transcription factors and gene expression, potentially affecting NIF-1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP, influencing transcriptional activity and potentially NIF-1 function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor, can affect chromatin structure and gene expression, potentially impacting NIF-1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences gene expression and cellular processes, potentially affecting NIF-1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, known to affect cell growth and gene expression, potentially influencing NIF-1. | ||||||